Evidence map›Paper›PMID 25196483›Full record

ReviewViruses2014

Mechanisms of HIV protein degradation into epitopes: implications for vaccine design.

Marijana Rucevic, Julie Boucau, Jens Dinter, Georgio Kourjian, Sylvie Le Gall

Open access · goldAbstract readReview

In one paragraph

Review in Viruses, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it

0cells of the map it votes in

7citing papers in PubMed

0.6field-weighted citation impact, top 35% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

The Activation State of CD4 T Cells Alters Cellular Peptidase Activities, HIV Antigen Processing, and MHC Class I Presentation in a Sequence-Dependent Manner.Journal of immunology (Baltimore, Md. : 1950) · 2019
Trial
Help or Hinder: Protein Host Factors That Impact HIV-1 Replication.Viruses · 2024
Review
APOBEC3G Regulation of the Evolutionary Race Between Adaptive Immunity and Viral Immune Escape Is Deeply Imprinted in the HIV Genome.Frontiers in immunology · 2018
Article
Analysis of Major Histocompatibility Complex-Bound HIV Peptides Identified from Various Cell Types Reveals Common Nested Peptides and Novel T Cell Responses.Journal of virology · 2016
Article
A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells.PLoS pathogens · 2016
Article
In vitro evaluation of digestive and endolysosomal enzymes to cleave CML-modified Ara h 1 peptides.Food science & nutrition · 2015
Article
Variable processing and cross-presentation of HIV by dendritic cells and macrophages shapes CTL immunodominance and immune escape.PLoS pathogens · 2015
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Marijana RucevicRagon Institute of MGH, MIT and Harvard, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA 02139, USA. Rucevic.Marijana@mgh.harvard.edu.

Julie BoucauRagon Institute of MGH, MIT and Harvard, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA 02139, USA. jnoucau@mgh.harvard.edu.

Jens DinterRagon Institute of MGH, MIT and Harvard, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA 02139, USA. jdinter@mgh.harvard.edu.

Georgio KourjianRagon Institute of MGH, MIT and Harvard, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA 02139, USA. gkourjian@mgh.harvard.edu.

Sylvie Le GallRagon Institute of MGH, MIT and Harvard, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA 02139, USA. sylvie_legall@hms.harvard.edu.

Ragon Institute of MGH, MIT and Harvard · US

Funding

Mechanisms and optimization of epitope presentation by HIV-infectable cell subsetR01AI084753 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LE GALL, SYLVIE · 2009 to 2013

$2.3M

Learning from attenuated CMV how to broaden HIV-specific T cell responsesR01AI112493 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LE GALL, SYLVIE · 2014 to 2017

$2.2M

Immune responses against HIV-induced cell-derived neoepitopes and HIV controlR01AI084106 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LE GALL, SYLVIE · 2009 to 2012

$2.1M

NIAID NIH HHS R01 AI084106NIAID NIH HHS R01 AI084753NIAID NIH HHS R01 AI112493PHS HHS NIAID R01 A1084753PHS HHS R01 A1084106

6 · The paper itself

Abstract

The degradation of HIV-derived proteins into epitopes displayed by MHC-I or MHC-II are the first events leading to the priming of HIV-specific immune responses and to the recognition of infected cells. Despite a wealth of information about peptidases involved in protein degradation, our knowledge of epitope presentation during HIV infection remains limited. Here we review current data on HIV protein degradation linking epitope production and immunodominance, viral evolution and impaired epitope presentation. We propose that an in-depth understanding of HIV antigen processing and presentation in relevant primary cells could be exploited to identify signatures leading to efficient or inefficient epitope presentation in HIV proteomes, and to improve the design of immunogens eliciting immune responses efficiently recognizing all infected cells.

Indexed as

Antigen PresentationAIDS VaccinesEpitopesHIVHIV AntigensHuman Immunodeficiency Virus ProteinsHumansProteolysisAIDS VaccinesEpitopesHIV AntigensHuman Immunodeficiency Virus Proteins

Identifiers

PMID25196483

DOI10.3390/v6083271

PMCPMC4147695

OpenAlexW2026210876

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.