ArticleInternational wound journal2016
A pilot study investigating lactic acid bacterial symbionts from the honeybee in inhibiting human chronic wound pathogens.
Article in International wound journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Isolation and probiotic evaluation of Apilactobacillus kunkeei and Bombella sp. from Apis mellifera anatoliaca and Bombus terrestris.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Antioxidant and Antimelanogenic Activities ofMicroorganisms · 2024Article
- Comprehensive analysis of the microbiome inPeerJ · 2024Article
- Hive Transplantation Has Minimal Impact on the Core Gut Microbiome of the Australian Stingless Bee, Tetragonula carbonaria.Microbial ecology · 2023Article
- Antimicrobial Properties, Functional Characterisation and Application of Fructobacillus fructosus and Lactiplantibacillus plantarum Isolated from Artisanal Honey.Probiotics and antimicrobial proteins · 2023Article
- Effect of honey bee forage plants in Tunisia on diversity and antibacterial potential of lactic acid bacteria and bifidobacteria from Apis mellifera intermissa and its products.Archives of microbiology · 2023Article
- Characterization of Lactic Acid Bacteria Strains Isolated from Algerian Honeybee and Honey and Exploration of Their Potential Probiotic and Functional Features for Human Use.Foods (Basel, Switzerland) · 2023Article
- Novel Candidate Microorganisms for Fermentation Technology: From Potential Benefits to Safety Issues.Foods (Basel, Switzerland) · 2022Review
- Honey as an Ecological Reservoir of Antibacterial Compounds Produced by Antagonistic Microbial Interactions in Plant Nectars, Honey and Honey Bee.Antibiotics (Basel, Switzerland) · 2021Review
- Investigation of the gut microbiome of Apis cerana honeybees from Vietnam.Biotechnology letters · 2020Article
- Potential Application ofFoods (Basel, Switzerland) · 2020Article
- Article
- The microbiome of the upper respiratory tract in health and disease.BMC biology · 2019Review
- Impact of probiotics on pathogen survival in an innovative human plasma biofilm model (hpBIOM).Journal of translational medicine · 2019Article
- Honeybee-Specific Lactic Acid Bacterium Supplements Have No Effect on American Foulbrood-Infected Honeybee Colonies.Applied and environmental microbiology · 2019Article
- Clinical efficacy of a topical lactic acid bacterial microbiome in chronic rhinosinusitis: A randomized controlled trial.Laryngoscope investigative otolaryngology · 2017Article
- Improvement of identification methods for honeybee specific Lactic Acid Bacteria; future approaches.PloS one · 2017Article
- Fighting Off Wound Pathogens in Horses with Honeybee Lactic Acid Bacteria.Current microbiology · 2016Article
- Functionally Structured Genomes in Lactobacillus kunkeei Colonizing the Honey Crop and Food Products of Honeybees and Stingless Bees.Genome biology and evolution · 2015Article
- Study of linkage between glutathione pathway and the antibiotic resistance of Escherichia coli from patients' swabs.International journal of molecular sciences · 2015Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Treatment and management of chronic wounds is a large burden on the health sector and causes substantial suffering for the patients. We believe that 13 lactic acid bacteria (LAB) symbionts isolated from the honey crop of the honeybee are important players in the antimicrobial action of honey, by producing antimicrobial substances and can be used in combination with heather honey as an effective treatment in wound management. A total of 22 patients with chronic ulcers were included; culture-dependent and molecular-based (MALDI-MS and 16S rRNA gene sequencing) techniques were used to identify bacteria from chronic wounds. These clinical isolates were used for in vitro antimicrobial testing with standardised viable LAB and sterilised heather honey mixture. Twenty of the patients' wounds were polymicrobial and 42 different species were isolated. Patient isolates that were tested in vitro were inhibited by the LAB and honey combination with inhibitory zones comparable with different antibiotics. LAB and heather honey in combination presents a new topical option in chronic wound management because of the healing properties of honey, antimicrobial metabolite production from the LAB and their bactericidal effect on common chronic wound pathogens. This new treatment may be a stepping stone towards an alternative solution to antibiotics.
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Registered trials
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