ArticleJournal of clinical hypertension (Greenwich, Conn.)2014
Vitamin D receptor genetic polymorphism is significantly associated with decreased risk of hypertension in a Chinese Han population.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Meta-Analysis of the Association Between the rs228570 Vitamin D Receptor Gene Polymorphism and Arterial Hypertension Risk.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Association between hypertension and risk of knee osteoarthritis: A meta-analysis of observational studies.Medicine · 2017Pooled it
- Vitamin D receptor gene variations and their association with cardiometabolic risk and microvascular complications in metabolic dysfunction-associated steatotic liver disease: evidence from a Turkish cohort.Laboratory medicine · 2026Article
- Article
- Fok I and Bsm I gene polymorphism of vitamin D receptor and essential hypertension: a mechanistic link.Clinical hypertension · 2023Review
- Vitamin D receptor deficiency increases systolic blood pressure by upregulating the renin-angiotensin system and autophagy.Experimental and therapeutic medicine · 2022Article
- Low serum 25-hydroxyvitamin D levels may increase the detrimental effect of VDR variants on the risk of essential hypertension.European journal of clinical nutrition · 2020Article
- Vitamin D receptor polymorphism rs2228570 is significantly associated with risk of dyslipidemia and serum LDL levels in Chinese Han population.Lipids in health and disease · 2018Article
- What do we know and do not know about vitamin D?: a causal association between vitamin D receptor genetic polymorphism and hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2014Article
- Association of AGTR1 (rs5186), VDR (rs2228570) genes polymorphism with blood pressure elevation in patients with essential arterial hypertension.Journal of medicine and lifeArticle
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the association of vitamin D receptor (VDR) gene polymorphism and hypertension in a Chinese Han population. The authors genotyped 3 tagSNPs (rs11574129, rs2228570, and rs739837) of the VDR gene using TaqMan assays in a case-control study including 2409 patients with hypertension and 3063 controls. The results showed that rs2228570 presented statistical correlations with decreased risk of male hypertension after adjustment for confounding factors, odds ratios (ORs) and 95% confidence intervals (CIs) of additive, dominant, and recessive models were 0.828 (0.74-0.927), 0.75 (0.631-0.89), and 0.816 (0.67-0.995), and P values were .001, .001, and .044, respectively. Significant associations were found in the smoking population and ORs (95% CIs) of additive and dominant models were 0.81 (0.69-0.952) and 0.71 (0.552-0.913) (P values .011 and .008), respectively, after adjustment for covariates. Quantitative trait analysis indicated that the untreated cases with TT genotype of rs2228570 showed higher systolic blood pressure compared with the TC/CC genotype (P=.015). Our findings suggest that VDR genetic polymorphism rs2228570 is significantly associated with the decreased risk of hypertension in Chinese men and smokers.
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