ReviewNeuroscience and biobehavioral reviews2015
Why do lesions in the rodent anterior thalamic nuclei cause such severe spatial deficits?
Review in Neuroscience and biobehavioral reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 106 citations in OpenAlex.
- Medial entorhinal VIP-expressing interneurons receive input from the thalamic anterior dorsal nucleus and are critical for spatial memory.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Distinct subnetworks of the mouse anterior thalamic nuclei.Nature communications · 2025Article
- Mapping global brain reconfigurations following local targeted manipulations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A glutamatergic innervation from medial area of secondary visual cortex to lateral posterior thalamic nucleus facilitates nociceptive and neuropathic pain.Communications biology · 2025Article
- Differentiated somatic gene expression is triggered in the dorsal hippocampus and the anterior retrosplenial cortex by hippocampal synaptic plasticity prompted by spatial content learning.Brain structure & function · 2024Article
- Article
- Photochemically induced thalamus infarction impairs cognition in a mouse model.Stroke and vascular neurology · 2023Article
- Binge-like ethanol exposure during the brain growth spurt disrupts the function of retrosplenial cortex-projecting anterior thalamic neurons in adolescent mice.Neuropharmacology · 2023Article
- Article
- Early Detection of Alzheimer's Disease in Postmenopausal Women Using Thalamic Subnuclear Volumetry.Journal of clinical medicine · 2023Article
- Explainable Vision Transformer with Self-Supervised Learning to Predict Alzheimer's Disease Progression Using 18F-FDG PET.Bioengineering (Basel, Switzerland) · 2023Article
- Convergence of location, direction, and theta in the rat anteroventral thalamic nucleus.iScience · 2023Article
- Cerebellar control of a unitary head direction sense.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Vision transformers for the prediction of mild cognitive impairment to Alzheimer's disease progression using mid-sagittal sMRI.Frontiers in aging neuroscience · 2023Article
- Anterior thalamic nuclei: A critical substrate for non-spatial paired-associate memory in rats.The European journal of neuroscience · 2022Article
- Time to retire the serial Papez circuit: Implications for space, memory, and attention.Neuroscience and biobehavioral reviews · 2022Review
- Article
- Where Actions Meet Outcomes: Medial Prefrontal Cortex, Central Thalamus, and the Basal Ganglia.Frontiers in behavioral neuroscience · 2022Review
- Midline Thalamic Damage Associated with Alcohol-Use Disorders: Disruption of Distinct Thalamocortical Pathways and Function.Neuropsychology review · 2021Review
- The anterior thalamic nuclei and cognition: A role beyond space?Neuroscience and biobehavioral reviews · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Lesions of the rodent anterior thalamic nuclei cause severe deficits to multiple spatial learning tasks. Possible explanations for these effects are examined, with particular reference to T-maze alternation. Anterior thalamic lesions not only impair allocentric place learning but also disrupt other spatial processes, including direction learning, path integration, and relative length discriminations, as well as aspects of nonspatial learning, e.g., temporal discriminations. Working memory tasks, such as T-maze alternation, appear particularly sensitive as they combine an array of these spatial and nonspatial demands. This sensitivity partly reflects the different functions supported by individual anterior thalamic nuclei, though it is argued that anterior thalamic lesion effects also arise from covert pathology in sites distal to the thalamus, most critically in the retrosplenial cortex and hippocampus. This two-level account, involving both local and distal lesion effects, explains the range and severity of the spatial deficits following anterior thalamic lesions. These findings highlight how the anterior thalamic nuclei form a key component in a series of interdependent systems that support multiple spatial functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.