ArticleInternational wound journal2016
Lactic acid bacterial symbionts in honeybees - an unknown key to honey's antimicrobial and therapeutic activities.
Article in International wound journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed.
- From bioactive compounds to volatile profiles: a multidimensional characterization of Indonesian stingless bee honeys.Journal of the science of food and agriculture · 2026Article
- Probiotic Characterization of Honey Bee-Associated Lactic Acid Bacteria and Their Impact on Colony Growth.Probiotics and antimicrobial proteins · 2026Article
- Probiotic Apilactobacillus Kunkeei EABW06 from Beeswax Microbiota: A Candidate for Functional Dairy Foods.Probiotics and antimicrobial proteins · 2026Article
- In Vivo and In Vitro Evaluation of Probiotic and Postbiotic Strategies Against Foulbrood in Honeybees.Probiotics and antimicrobial proteins · 2026Article
- Apilactobacillus kunkeei as a promising fermentation candidate for reducing free sugars in fruit juices.BMC microbiology · 2026Article
- Genome-resolved metagenomics reveals a phylogenetically cohesiveISME communications · 2026Article
- Holobiont-holobiont interactions across host-ectoparasite systems.Parasites & vectors · 2025Review
- Isolation and probiotic evaluation of Apilactobacillus kunkeei and Bombella sp. from Apis mellifera anatoliaca and Bombus terrestris.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Lactic Acid Bacteria: A Probiotic to Mitigate Pesticide Stress in Honey Bee.Probiotics and antimicrobial proteins · 2025Review
- Medical Potential of Insect Symbionts.Insects · 2025Review
- Probiotics and postbiotics: a promising prophylactic measure for American foulbrood and European foulbrood diseases of honey bees.Veterinary research forum : an international quarterly journal · 2025Article
- Composition of Proteins Associated with Red Clover (Life (Basel, Switzerland) · 2024Article
- Review
- Lactic acid bacteria in Swedish honey bees during outbreaks of American foulbrood.Ecology and evolution · 2024Article
- Article
- Comprehensive analysis of the microbiome inPeerJ · 2024Article
- Antibacterial activity of exopolysaccharide produced by bee gut-resident Enterococcus sp. BE11 against marine fish pathogens.BMC microbiology · 2023Article
- Effect of honey bee forage plants in Tunisia on diversity and antibacterial potential of lactic acid bacteria and bifidobacteria from Apis mellifera intermissa and its products.Archives of microbiology · 2023Article
- Characterization of Lactic Acid Bacteria Strains Isolated from Algerian Honeybee and Honey and Exploration of Their Potential Probiotic and Functional Features for Human Use.Foods (Basel, Switzerland) · 2023Article
- Biocontrol potential of Apilactobacillus kunkeei EIR/BG-1 against infectious diseases in honey bees (Apis mellifera L.).Veterinary research communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Could honeybees' most valuable contribution to mankind besides pollination services be alternative tools against infections? Today, due to the emerging antibiotic-resistant pathogens, we are facing a new era of searching for alternative tools against infections. Natural products such as honey have been applied against human's infections for millennia without sufficient scientific evidence. A unique lactic acid bacterial (LAB) microbiota was discovered by us, which is in symbiosis with honeybees and present in large amounts in fresh honey across the world. This work investigates if the LAB symbionts are the source to the unknown factors contributing to honey's properties. Hence, we tested the LAB against severe wound pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa and vancomycin-resistant Enterococcus (VRE) among others. We demonstrate a strong antimicrobial activity from each symbiont and a synergistic effect, which counteracted all the tested pathogens. The mechanisms of action are partly shown by elucidating the production of active compounds such as proteins, fatty acids, anaesthetics, organic acids, volatiles and hydrogen peroxide. We show that the symbionts produce a myriad of active compounds that remain in variable amounts in mature honey. Further studies are now required to investigate if these symbionts have a potential in clinical applications as alternative tools against topical human and animal infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.