ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015
Child psychiatry branch of the National Institute of Mental Health longitudinal structural magnetic resonance imaging study of human brain development.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
155 citing papers in PubMed, 5 syntheses or guidelines pooled it, 310 citations in OpenAlex.
- Neural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysis.Schizophrenia research · 2024Pooled it
- The brain in social context: A systematic review of substance use and social processing from adolescence to young adulthood.Developmental cognitive neuroscience · 2022Pooled it
- Decision-making and cognitive control in adolescent suicidal behaviors: a qualitative systematic review of the literature.European child & adolescent psychiatry · 2021Pooled it
- Structural white matter changes in adults and children with posttraumatic stress disorder: A systematic review and meta-analysis.NeuroImage. Clinical · 2018Pooled it
- Adolescent brain development and depression: A case for the importance of connectivity of the anterior cingulate cortex.Neuroscience and biobehavioral reviews · 2016Pooled it
- Influences of Brain Size, Sex, and Sex Chromosome Complement on the Architecture of Human Cortical Folding.Cerebral cortex (New York, N.Y. : 1991) · 2017Trial
- Longitudinal neurocognitive trajectories in a large cohort of youth who use cannabis: combining self-report and toxicology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Developing a multi-modal neuroimaging-based BrainAge model across childhood.bioRxiv : the preprint server for biology · 2026Article
- Continual learning of multiple cognitive functions with a brain-inspired temporal development mechanism.National science review · 2026Article
- Neural subtypes in developmental stuttering.bioRxiv : the preprint server for biology · 2026Article
- Structural network alterations in adolescent major depression and bipolar disorder: a graph-theoretical and fixel-based analysis.BMC psychiatry · 2026Article
- Longitudinal Neurocognitive Trajectories in a Large Cohort of Youth Who Use Cannabis: Combining Self-Report and Toxicology.bioRxiv : the preprint server for biology · 2026Article
- Article
- Regional and Global Changes in Brain Structure 1-Year Post Pediatric "Mild" Traumatic Brain Injury.Annals of neurology · 2025Article
- Developmental Changes in Brain Cellular Membrane and Energy Metabolism: A Multi-occasionThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- More similarity than difference: Comparison of within- and between-sex variance in early adolescent brain structure.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- More similarity than difference: comparison of within- and between-sex variance in early adolescent brain structure.Research square · 2024Article
- The genetics of spatiotemporal variation in cortical thickness in youth.Communications biology · 2024Article
- Mapping Age Differences in Brain Energy Metabolites and Metabolic Markers of Cellular Membrane Production and Degradation WithHuman brain mapping · 2024Article
- Neuroimaging of posttraumatic stress disorder in adults and youth: progress over the last decade on three leading questions of the field.Molecular psychiatry · 2024Review
95 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The advent of magnetic resonance imaging, which safely allows in vivo quantification of anatomical and physiological features of the brain, has revolutionized pediatric neuroscience. Longitudinal studies are useful for the characterization of developmental trajectories (ie, changes in imaging measures by age). Developmental trajectories (as opposed to static measures) have proven to have greater power in discriminating healthy from clinical groups and in predicting cognitive/behavioral measures, such as IQ. Here we summarize results from an ongoing longitudinal pediatric neuroimaging study that has been conducted at the Child Psychiatry Branch of the National Institute of Mental Health since 1989. Developmental trajectories of structural MRI brain measures from healthy youth are compared and contrasted with trajectories in attention-deficit/hyperactivity disorder (ADHD) and childhood-onset schizophrenia. Across ages 5-25 years, in both healthy and clinical populations, white matter volumes increase and gray matter volumes follow an inverted U trajectory, with peak size occurring at different times in different regions. At a group level, differences related to psychopathology are seen for gray and white matter volumes, rates of change, and for interconnectedness among disparate brain regions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.