Trial reportPsychopharmacology2015
A single dose of antidepressant alters eye-gaze patterns across face stimuli in healthy women.
Trial report in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Effects of Anodal Transcranial Direct Current Stimulation and Serotonergic Enhancement on Memory Performance in Young and Older Adults.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Serotonergic Suppression of Sustained Synaptic Responses in Rat Oculomotor Neural Integrator Networks.eNeuro · 2025Article
- Increasing Central Serotonin with 5-hydroxytryptophan Disrupts the Inhibition of Social Gaze in Nonhuman Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Gaze instability after exposure to moving visual stimuli in patients with persistent postural-perceptual dizziness.Frontiers in human neuroscience · 2022Article
- Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment.Psychopharmacology · 2021Review
- Cognitive Control, Cognitive Biases and Emotion Regulation in Depression: A New Proposal for an Integrative Interplay Model.Frontiers in psychology · 2021Review
- Differences in how macaques monitor others: Does serotonin play a central role?Wiley interdisciplinary reviews. Cognitive science · 2019Review
- Methoxetamine affects brain processing involved in emotional response in rats.British journal of pharmacology · 2017Article
- The µ-opioid system promotes visual attention to faces and eyes.Social cognitive and affective neuroscience · 2016Article
- The effects of drugs on human models of emotional processing: an account of antidepressant drug treatment.Dialogues in clinical neuroscience · 2015Review
- A neurocognitive model for understanding treatment action in depression.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly neurocognitive changes in emotional processing are seen following SSRI administration, which may be involved in mechanisms of action. However, the perceptual processes underpinning these effects have not been specified.
methodsIn a double-blind, placebo-controlled eye-tracking study, we assessed the effect of single dose of citalopram (20 mg) in 25 healthy females. Face stimuli with direct and averted gaze were presented while visual scan patterns and pupil sizes were monitored. Subjective state was monitored using visual analogue scales.
resultsThere were no significant effects of citalopram on subjective state. However, the citalopram group displayed increased saccade numbers and shorter fixation duration during face viewing compared to the placebo group. Volunteers receiving citalopram also showed reduced monitoring of the eye region irrespective of the direct or averted eye position of the stimuli. The citalopram group also showed significantly larger pupil sizes than the control group.
conclusionsThese results suggest that the SSRI administration affects the perceptual processing of face stimuli. The current pattern of findings is consistent with anxiogenic-like mechanisms early on in SSRI treatment. Eye-tracking provides a novel method to characterise and detect these effects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.