Evidence map›Paper›PMID 25194450›Full record

Trial reportArchives of physical medicine and rehabilitation2015

Resistance training reduces disability in prostate cancer survivors on androgen deprivation therapy: evidence from a randomized controlled trial.

Kerri M Winters-Stone, Jessica C Dobek, Jill A Bennett, Nathan F Dieckmann, Gianni F Maddalozzo, Christopher W Ryan, Tomasz M Beer

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of physical medicine and rehabilitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07572760 (Low to Moderate Load Power Training as an Exercise Intervention for Men With Metastatic Prostate Cancer Undergoing Androgen Deprivation Therapy.), which is not on this map. Cited by 68 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 18 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07572760 narecruitingnot on this mapstarted 2024, after this paper: background citation

Low to Moderate Load Power Training as an Exercise Intervention for Men With Metastatic Prostate Cancer Undergoing Androgen Deprivation Therapy.

TypeinterventionalSponsorUniversity of AlicanteRan2024 to 2026Enrolled66ConditionsProstatic NeoplasmsArmsPower training group
3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 18 syntheses or guidelines pooled it, 128 citations in OpenAlex.

  1. Pooled it
  2. Resistance training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2024
    Pooled it
  3. Pooled it
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  7. Do Patients with Prostate Cancer Benefit from Exercise Interventions? A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
  8. Pooled it
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  10. The effectiveness of lifestyle interventions to reduce side effects of androgen deprivation therapy for men with prostate cancer: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020
    Pooled it
  11. Pooled it
  12. Guideline
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  16. Effects of resistance exercise in prostate cancer patients: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017
    Pooled it
  17. Pooled it
  18. The effects of resistance exercise on physical performance and health-related quality of life in prostate cancer patients: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015
    Pooled it
  19. Trial
  20. Trial

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kerri M Winters-StoneKnight Cancer Institute, Oregon Health & Science University, Portland, OR; School of Nursing, Oregon Health & Science University, Portland, OR. Electronic address: wintersk@ohsu.edu.
Jessica C DobekSchool of Nursing, Oregon Health & Science University, Portland, OR.
Jill A BennettKnight Cancer Institute, Oregon Health & Science University, Portland, OR; School of Nursing, Oregon Health & Science University, Portland, OR.
Nathan F DieckmannSchool of Nursing, Oregon Health & Science University, Portland, OR.
Gianni F MaddalozzoDepartment of Exercise and Sport Science, School of Biologic and Population Health, Oregon State University, Corvallis, OR.
Christopher W RyanKnight Cancer Institute, Oregon Health & Science University, Portland, OR; School of Medicine, Oregon Health & Science University, Portland, OR.
Tomasz M BeerKnight Cancer Institute, Oregon Health & Science University, Portland, OR; School of Medicine, Oregon Health & Science University, Portland, OR.
Oregon Health & Science University · USOregon State University · US

Funding

Understanding the origins of rapid recurrence of pancreatic cancer after resectionP30CA069533 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Grace B Gill · 1997 to 2026
$60.5M
NCI NIH HHS P30 CA069533
6 · The paper itself

Abstract

objectivesTo investigate whether functionally based resistance exercise could improve strength, physical function, and disability among prostate cancer survivors (PCS) on androgen deprivation therapy (ADT); and to explore potential mediators of changes in outcomes from exercise.

designRandomized controlled trial.

settingAcademic medical center.

participantsPCS (N=51; mean age, 70.2y) on ADT.

interventionPCS were randomized to moderate to vigorous intensity resistance training or stretching (placebo control) for 1 year.

main outcome measuresMaximal leg press and bench press strength, objective and self-reported physical function, and self-reported disability. Hierarchical linear modeling was used to test for significant group × time differences adjusting for covariates.

resultsRetention in the study was 84%, and median attendance to supervised classes was 84% in the resistance group. No study-related injuries occurred. Maximal leg strength (P=.032) and bench press strength (P=.027) were improved after 1 year of resistance training, whereas little change occurred from stretching. Self-reported physical function improved with resistance training, whereas decreases occurred from stretching (P=.016). Disability lessened more with resistance training than stretching (P=.018). One-year change in leg press strength mediated the relation between groups (resistance or stretching) and 1-year change in self-reported disability (P<.05).

conclusionsOne year of resistance training improved muscle strength in androgen-deprived PCS. Strengthening muscles using functional movement patterns may be an important feature of exercise programs designed to improve perceptions of physical function and disability. Findings from this study contribute to the mounting evidence that exercise should become a routine part of clinical care in older men with advanced prostate cancer.

Indexed as

Academic Medical CentersAgedAndrogen AntagonistsDisability EvaluationHealth StatusHumansMaleMiddle AgedMuscle, SkeletalMuscle StrengthProstatic NeoplasmsQuality of LifeResistance TrainingAndrogen AntagonistsActivities of daily livingExerciseMenMuscle strengthNeoplasmRehabilitationStrength training

Identifiers

PMID25194450
PMCPMC4433162
OpenAlexW1984991116

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.