Evidence map›Paper›PMID 25194290›Full record

ArticleJACC. Heart failure2014

Association of obesity in early adulthood and middle age with incipient left ventricular dysfunction and structural remodeling: the CARDIA study (Coronary Artery Risk Development in Young Adults).

Satoru Kishi, Anderson C Armstrong, Samuel S Gidding, Laura A Colangelo, Bharath A Venkatesh, David R Jacobs, J Jeffery Carr, James G Terry, Kiang Liu, David C Goff and 1 more

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In one paragraph

Article in JACC. Heart failure, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

  1. Trial
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  19. Therapeutic Stalemate in Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2021
    Review
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Satoru KishiJohns Hopkins University, Baltimore, Maryland.
Anderson C ArmstrongJohns Hopkins University, Baltimore, Maryland.
Samuel S GiddingNemours Cardiac Center, Wilmington, Delaware.
Laura A ColangeloNorthwestern University, Chicago, Illinois.
Bharath A VenkateshJohns Hopkins University, Baltimore, Maryland.
David R JacobsUniversity of Minnesota School of Public Health, Minneapolis, Minnesota.
J Jeffery CarrVanderbilt University School of Medicine, Nashville, Tennessee.
James G TerryWake Forest University School of Medicine, Winston-Salem, North Carolina.
Kiang LiuNorthwestern University, Chicago, Illinois.
David C GoffColorado School of Public Health, Aurora, Colorado.
João A C LimaJohns Hopkins University, Baltimore, Maryland. Electronic address: jlima@jhmi.edu.

Funding

Intramural NIH HHSNHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS HHSN268201400018CNIA NIH HHS AG0005
6 · The paper itself

Abstract

objectivesThe goal of this study was to investigate the relationship of body mass index (BMI) and its 25-year change to left ventricular (LV) structure and function.

backgroundLongstanding obesity may be associated with clinical cardiac dysfunction and heart failure. Whether obesity relates to cardiac dysfunction during young adulthood and middle age has not been investigated.

methodsThe CARDIA (Coronary Artery Risk Development in Young Adult) study enrolled white and black adults ages 18 to 30 years in 1985 to 1986 (Year-0). At Year-25, cardiac function was assessed by conventional echocardiography, tissue Doppler imaging (TDI), and speckle tracking echocardiography (STE). Twenty-five-year change in BMI (classified as low: <27 kg/m(2) and high: ≥27 kg/m(2)) was categorized into 4 groups (Low-Low, High-Low, Low-High, and High-High). Multiple linear regression was used to quantify the association between categorical changes in BMI (Low-Low as reference) with LV structural and functional parameters obtained in middle age, adjusting for baseline and 25-year change in risk factors.

resultsThe mean BMI was 24.4 kg/m(2) in 3,265 participants included at Year-0. Change in BMI adjusted for risk factors was directly associated with incipient myocardial systolic dysfunction assessed by STE (High-High: β-coefficient = 0.67; Low-High: β-coefficient = 0.35 for longitudinal peak systolic strain) and diastolic dysfunction assessed by TDI (High-High: β-coefficient = -074; Low-High: β-coefficient = -0.45 for e') and STE (High-High: β-coefficient = -0.06 for circumferential early diastolic strain rate). Greater BMI was also significantly associated with increased LV mass/height (High-High: β-coefficient = 26.11; Low-High: β-coefficient = 11.87).

conclusionsLongstanding obesity from young adulthood to middle age is associated with impaired LV systolic and diastolic function assessed by conventional echocardiography, TDI, and STE in a large biracial cohort of adults age 43 to 55 years.

Indexed as

Ventricular RemodelingAdolescentAdultBlack or African AmericanBody Mass IndexCohort StudiesDiabetes MellitusDyslipidemiasEchocardiographyFemaleHumansMaleMiddle AgedObesityProspective StudiesRisk Factorsechocardiographyleft ventricular functionleft ventricular remodelingobesityrisk factorsspeckle tracking echocardiographytissue Doppler imaging

Identifiers

PMID25194290
PMCPMC4194150

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.