ReviewThe Journal of pharmacology and experimental therapeutics2014
Stress-induced pain: a target for the development of novel therapeutics.
Review in The Journal of pharmacology and experimental therapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Peritraumatic Pain in Child Maltreatment: A Systematic Literature Review.Trauma, violence & abuse · 2024Pooled it
- Trauma and physical pain: an urban-rural comparison of sexually abused girls in Burundi.European journal of psychotraumatology · 2025Article
- Effect of Spinal Cord Response on Changes in Pain Thresholds of Each Tissue Due to Electroacupuncture.Medical acupuncture · 2025Article
- Design, Synthesis, andACS omega · 2024Article
- Reproducible microbiome composition signatures of anxiety and depressive symptoms.Computational and structural biotechnology journal · 2023Article
- Resilience, pain, and the brain: Relationships differ by sociodemographics.Journal of neuroscience research · 2021Observational
- Interrelations between pain, stress and executive functioning.British journal of pain · 2020Article
- Anti-stress neuropharmacological mechanisms and targets for addiction treatment: A translational framework.Neurobiology of stress · 2018Review
- Different predictors of pain severity across age and gender of a Chinese rural population: a cross-sectional survey.BMJ open · 2018Article
- Secondary traumatic stress increases expression of proteins implicated in peripheral and central sensitization of trigeminal neurons.Brain research · 2018Article
- Impact of chemotherapy-induced neurotoxicities on adult cancer survivors' symptom burden and quality of life.Journal of cancer survivorship : research and practice · 2018Article
- The peripheral corticotropin-releasing factor (CRF)-induced analgesic effect on somatic pain sensitivity in conscious rats: involving CRF, opioid and glucocorticoid receptors.Inflammopharmacology · 2018Review
- The Effects of Chronic Stress on Migraine Relevant Phenotypes in Male Mice.Frontiers in cellular neuroscience · 2018Article
- Complementary and alternative medicine therapies for chronic pain.Chinese journal of integrative medicine · 2016Review
- Corrigendum to "Chronic stress and peripheral pain: Evidence for distinct, region-specific changes in visceral and somatosensory pain regulatory pathways" [Exp Neurol. 2015 Nov.; 273: 301-11].Experimental neurology · 2016Article
- Chronic stress and peripheral pain: Evidence for distinct, region-specific changes in visceral and somatosensory pain regulatory pathways.Experimental neurology · 2015Article
- Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities.Frontiers in psychiatry · 2015Review
- Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain.Neurobiology of stress · 2015Article
- Could Stress Contribute to Pain-Related Fear in Chronic Pain?Frontiers in behavioral neuroscience · 2015Article
- The janus face of stress on reproduction: from health to disease.International journal of endocrinology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Although current therapeutics provide relief from acute pain, drugs used for treatment of chronic pain are typically less efficacious and limited by adverse side effects, including tolerance, addiction, and gastrointestinal upset. Thus, there is a significant need for novel therapies for the treatment of chronic pain. In concert with chronic pain, persistent stress facilitates pain perception and sensitizes pain pathways, leading to a feed-forward cycle promoting chronic pain disorders. Stress exacerbation of chronic pain suggests that centrally acting drugs targeting the pain- and stress-responsive brain regions represent a valid target for the development of novel therapeutics. This review provides an overview of how stress modulates spinal and central pain pathways, identifies key neurotransmitters and receptors within these pathways, and highlights their potential as novel targets for therapeutics to treat chronic pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.