ArticleJournal of the American Society of Nephrology : JASN2015
IgD heavy-chain deposition disease: detection by laser microdissection and mass spectrometry.
Article in Journal of the American Society of Nephrology : JASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group.Nature reviews. Nephrology · 2019Guideline
- A case of immunofluorescence-negative light chain deposition disease diagnosed by mass spectrometry.CEN case reports · 2026Article
- A case of heavy-chain deposition disease with good long-term renal survival and a literature review.BMC nephrology · 2024Review
- Randall-Type Monoclonal IgE Kappa Light-Heavy Chain Deposition Disease.Kidney international reports · 2023Article
- Monoclonal Gammopathy of Renal Significance: A Molecular Middle Earth between Oncology, Nephrology, and Pathology.Kidney diseases (Basel, Switzerland) · 2022Review
- A Fresh Perspective on Monoclonal Gammopathies of Renal Significance.Kidney international reports · 2021Review
- Light chain deposition disease involving kidney and liver in a patient with IgD myeloma.BMC nephrology · 2021Article
- [Advances in diagnosis and treatment of monoclonal immunoglobulin deposit disease].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2020Article
- α1-Heavy Chain Deposition Disease With Negative Immunofluorescence Staining on Renal Biopsy.Kidney international reports · 2019Article
- The Complexity and Heterogeneity of Monoclonal Immunoglobulin-Associated Renal Diseases.Journal of the American Society of Nephrology : JASN · 2018Review
- Monoclonal gammopathy of renal significance: Diagnostic workup.World journal of nephrology · 2017Review
- Characterization of glomerular extracellular matrix by proteomic analysis of laser-captured microdissected glomeruli.Kidney international · 2017Article
- Coexistence of Light- and Heavy-Chain Deposition Disease and Immunotactoid Glomerulopathy in a Patient with Multiple Myeloma: A Case Report.Case reports in nephrology and dialysisArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monoclonal Ig deposition disease (MIDD) is a rare complication of monoclonal gammopathy characterized by deposition of monoclonal Ig light chains and/or heavy chains along the glomerular and tubular basement membranes. Here, we describe a unique case of IgD deposition disease. IgD deposition is difficult to diagnose, because routine immunofluorescence does not detect IgD. A 77-year-old man presented with proteinuria and renal failure, and kidney biopsy analysis showed a nodular sclerosing GN with extensive focal global glomerulosclerosis, tubular atrophy, and interstitial fibrosis. Immunofluorescence was negative for Ig deposits, although electron microscopy showed deposits in the glomeruli and along tubular basement membranes. Laser microdissection of glomeruli and mass spectrometry of extracted peptides showed a large spectra number for IgD, and immunohistochemistry showed intense glomerular and tubular staining for IgD. Together, these findings are consistent with IgD deposition disease. Bone marrow biopsy analysis showed 5% plasma cells, which stained for IgD. The patient was treated with bortezomib and dexamethasone, which resulted in improvement of hematologic parameters but no improvement of renal function. The diagnosis of IgD deposition disease underscores the value of laser microdissection and mass spectrometry in further evaluating renal biopsies when routine assessment fails to reach an accurate diagnosis.
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