Evidence map›Paper›PMID 25193962›Full record

ArticleHaematologica2014

Critical role of SHP2 (PTPN11) signaling in germinal center-derived lymphoma.

Xin Jiang, Honggang Guo, Jianguo Wu, Qiang He, Yiqiao Li, Miao Wang, Hongyang Pan, Wande Li, Jinjie Wang, Qingqing Wang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Ratiometric transcriptional activation by protein degradation.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Xin JiangDepartment of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China.
Honggang GuoDepartment of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China.
Jianguo WuDepartment of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China.
Qiang HeDepartment of Nephrology, Zhejiang Province People's Hospital, Hangzhou, China.
Yiqiao LiDepartment of Nephrology, Zhejiang Province People's Hospital, Hangzhou, China.
Miao WangDepartment of Pathology, Basic Medical College, Capital Medical University, Beijing, China.
Hongyang PanCentral Laboratory, Epitomics (Hangzhou) Biotech Co. Ltd, Hangzhou, Zhejiang, China.
Wande LiDepartment of Biochemistry, Boston University School of Medicine, MA, USA.
Jinjie WangDepartment of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China.
Qingqing WangDepartment of Immunology, Zhejiang University School of Medicine, Hangzhou, China.
Jing ShenDepartment of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China.
Yuehai KeDepartment of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China.
Ren ZhouDepartment of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China zhouren@zju.edu.cn.
Zhejiang University · CNBoston University · USCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Germinal center lymphoma is a heterogeneous human lymphoma entity. Here we report that constitutive activity of SHP2 (PTPN11) and its downstream kinase ERK is essential for the viability of germinal center lymphoma cells and disease progression. Mechanistically, SHP2/ERK inhibition impedes c-Myc transcriptional activity, which results in the repression of proliferative phenotype signatures of germinal center lymphoma. Furthermore, SHP2/ERK signaling is required to maintain the CD19/c-Myc loop, which preferentially promotes survival of a distinct subtype of germinal center lymphoma cells carrying the MYC/IGH translocation. These findings demonstrate a critical function for SHP2/ERK signaling upstream of c-Myc in germinal center lymphoma cells and provide a rationale for targeting SHP2 in the therapy of germinal center lymphoma.

Indexed as

ApoptosisBlotting, WesternCell CycleCell ProliferationFlow CytometryFluorescent Antibody TechniqueGerminal CenterHumansImmunoenzyme TechniquesImmunoglobulin Heavy ChainsImmunoprecipitationLymphomaMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Protein Tyrosine Phosphatase, Non-Receptor Type 11Proto-Oncogene Proteins c-mycImmunoglobulin Heavy ChainsMAPK1 protein, humanMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Protein Tyrosine Phosphatase, Non-Receptor Type 11Proto-Oncogene Proteins c-mycPTPN11 protein, humanRNA, MessengerRNA, Small Interfering

Identifiers

PMID25193962
PMCPMC4258751
OpenAlexW2098189230

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.