ArticleG3 (Bethesda, Md.)2014
Whole-genome expression analysis in the third instar larval midgut of Drosophila melanogaster.
Article in G3 (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Detoxification mechanisms of black soldier fly larvae against microcystin-LR.Functional & integrative genomics · 2026Article
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- Microbiome-emitted scents activate olfactory neuron-independent airway-gut-brain axis to promote host growth in Drosophila.Nature communications · 2025Article
- Characterization of a novel pesticide transporter and P-glycoprotein orthologues inProceedings. Biological sciences · 2022Article
- Article
- Anatomy and Physiology of the Digestive Tract ofGenetics · 2018Review
- Dual Roles of Glutathione in Ecdysone Biosynthesis and Antioxidant Function During Larval Development inGenetics · 2017Article
- Partitioning the roles of CYP6G1 and gut microbes in the metabolism of the insecticide imidacloprid in Drosophila melanogaster.Scientific reports · 2017Article
- Naturally Segregating Variation atGenetics · 2017Article
- Organ-to-Organ Communication: AFrontiers in cell and developmental biology · 2017Review
- Evolution, Expression, and Function of Nonneuronal Ligand-Gated Chloride Channels in Drosophila melanogaster.G3 (Bethesda, Md.) · 2016Article
- Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila.PLoS genetics · 2015Article
- Mechanisms and ecological consequences of plant defence induction and suppression in herbivore communities.Annals of botany · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Survival of insects on a substrate containing toxic substances such as plant secondary metabolites or insecticides is dependent on the metabolism or excretion of those xenobiotics. The primary sites of xenobiotic metabolism are the midgut, Malpighian tubules, and fat body. In general, gene expression in these organs is reported for the entire tissue by online databases, but several studies have shown that gene expression within the midgut is compartmentalized. Here, RNA sequencing is used to investigate whole-genome expression in subsections of third instar larval midguts of Drosophila melanogaster. The data support functional diversification in subsections of the midgut. Analysis of the expression of gene families that are implicated in the metabolism of xenobiotics suggests that metabolism may not be uniform along the midgut. These data provide a starting point for investigating gene expression and xenobiotic metabolism and other functions of the larval midgut.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.