ReviewDigestive diseases and sciences2014
Cholecystectomy for biliary dyskinesia: how did we get there?
Review in Digestive diseases and sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Comparison of laparoscopic cholecystectomy in children at paediatric centres and adult centres: a systematic review and meta-analysis.Annals of the Royal College of Surgeons of England · 2025Pooled it
- Systematic review and meta-analyses of cholecystectomy as a treatment of biliary hyperkinesia.Clinical journal of gastroenterology · 2021Pooled it
- Pilot Randomized Controlled Trial of Laparoscopic Cholecystectomy vs Active Nonoperative Therapy for the Treatment of Biliary Dyskinesia.Journal of the American College of Surgeons · 2016Trial
- Biliary Dyskinesia with Reduced Gallbladder Ejection Fraction: A Diagnostic and Therapeutic Shift in Management.Journal of Brown hospital medicine · 2025Article
- Article
- Use of endoscopic gallbladder stenting and biliary scintigraphy for diagnosis of gallbladder dyskinesia: a case report.Clinical journal of gastroenterology · 2023Article
- The Chronic Acalculous Symptomatic Hyperkinetic (CASPER) Gallbladder or "JSM gastroenterology and hepatology · 2023Article
- Biliary hyperkinesia in adolescents-it isn't all hype!Translational gastroenterology and hepatology · 2021Article
- Biliary Dyskinesia in Children and Adolescents: A Mini Review.Frontiers in pediatrics · 2020Review
- Is functional gallbladder disease truly increasing? Results from the Rochester Epidemiology Project.American journal of surgery · 2018Article
- How much pain relief do patients expect after cholecystectomy?Surgical endoscopy · 2018Article
- Sphincter of Oddi Function and Risk Factors for Dysfunction.Frontiers in nutrition · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe focus of biliary dyskinesia (BD) shifted within the last 30 years, moving from symptoms after cholecystectomy (CCY) to symptoms with morphological normal gallbladder, but low gallbladder ejection fraction.
methodsWe searched the pubmed database to systematically review studies focusing on the diagnosis and treatment of gallbladder dysfunction.
resultsImpaired gallbladder contraction can be found in about 20% of healthy controls and an even higher number of patients with various other disorders. Surgery for BD increased after introduction of laparoscopic CCY, with BD now accounting for >20% of CCY in adults and up to 60% in pediatric patients. The majority of cases reported were operated in the USA, which differs from surgical series for cholelithiasis. Postoperative outcomes do not differ between groups with abnormal or normal gallbladder function.
conclusionFunctional gallbladder testing should not be seen as an indicator of relevant biliary tract disease or prognostic marker to identify patients who may benefit from operative intervention. Instead biliary dyskinesia should be considered as a part of a spectrum of functional disorders, which are generally managed conservatively. Small proof of concept studies have demonstrated effects of medical therapy on biliary dysfunction and should thus be never tested in appropriately designed trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.