ReviewCurrent diabetes reports2014
How to treat erectile dysfunction in men with diabetes: from pathophysiology to treatment.
Review in Current diabetes reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
- ICNPReports (MDPI) · 2026Article
- Risky business: penile prosthesis in high-risk patients.Translational andrology and urology · 2025Article
- Elevated uric acid induces erectile dysfunction in rats by interacting with MLCK and inhibiting its ubiquitin-mediated degradation.Communications biology · 2025Article
- Ursodeoxycholic acid ameliorates erectile dysfunction and corporal fibrosis in diabetic rats by inhibiting the TGF-β1/Smad2 pathway.International journal of impotence research · 2024Article
- Stem cell therapy in diabetic men with erectile dysfunction: a 24-month follow-up of safety and efficacy of two intracavernous autologous bone marrow derived mesenchymal stem cells injections, an open label phase 2 clinical trial.Basic and clinical andrology · 2024Article
- Intracavernous Injection of Platelet-Rich Plasma Therapy Enhances Erectile Function and Decreases the Mortality Rate in Streptozotocin-Induced Diabetic Rats.International journal of molecular sciences · 2022Article
- Traditional chinese medicine to prevent and treat diabetic erectile dysfunction.Frontiers in pharmacology · 2022Review
- Knockdown of miR-423-5p simultaneously upgrades the eNOS and VEGFa pathways in ADSCs and improves erectile function in diabetic rats.Journal of cellular and molecular medicine · 2021Article
- Undiagnosed prediabetes status is associated with a reduced effectiveness of phosphodiesterase type 5 inhibitors in men with erectile dysfunction.International journal of impotence research · 2020Article
- Mitochondrial ATP synthase regulates corpus cavernosum smooth muscle cell functionExperimental and therapeutic medicine · 2020Article
- A novel drug-drug coamorphous system without molecular interactions: improve the physicochemical properties of tadalafil and repaglinide.RSC advances · 2019Article
- Cavernosal hydrogen sulfide levels are associated with nitric oxide and hemeoxygenase levels in diabetic rats.International journal of impotence research · 2019Article
- Diabetes Is a Risk Factor for Inflatable Penile Prosthesis Infection: Analysis of a Large Statewide Database.Sexual medicine · 2019Article
- Diagnosis of erectile dysfunction can be used to improve screening for Type 2 diabetes mellitus.Diabetic medicine : a journal of the British Diabetic Association · 2018Article
- Islet transplantation improved penile tissue fibrosis in a rat model of type 1 diabetes.BMC endocrine disorders · 2018Article
- Defining a glycated haemoglobin (HbA1c) level that predicts increased risk of penile implant infection.BJU international · 2018Article
- Psychosocial Care for People With Diabetes: A Position Statement of the American Diabetes Association.Diabetes care · 2016Review
- Hyperhomocysteinaemia in rats is associated with erectile dysfunction by impairing endothelial nitric oxide synthase activity.Scientific reports · 2016Article
- Effects of adipose-derived stem cells plus insulin on erectile function in streptozotocin-induced diabetic rats.International urology and nephrology · 2016Article
- A review of the efficacy and safety of mirodenafil in the management of erectile dysfunction.Therapeutic advances in urology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Erectile dysfunction (ED) is highly prevalent affecting at least 50 % of men with diabetes mellitus (DM). DM may cause ED through a number of pathophysiological pathways. These include neuropathy, endothelial dysfunction, cavernosal smooth muscle structural/functional changes, and hormonal changes. Lifestyle changes, diabetes control, and treatment of hypogonadism are important as the first step in ED management since there is no curative treatment for ED. Phosphodiesterase type 5 inhibitors (PDE5i) are the first-line treatment option. Intracavernous administration of vasoactive drugs is commonly used as a second-line medical treatment when PDE5i have failed. Alprostadil is the most widely used drug in this second-line setting. The combination of papaverine, phentolamine, and alprostadil represents the most efficacious intracavernous pharmacologic treatment option that may save non-responders to alprostadil. Penile prosthesis implantation can be considered in treatment refractory cases, with excellent functional and safety results in the properly informed patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.