ArticleGenome biology and evolution2014
Natural selection on coding and noncoding DNA sequences is associated with virulence genes in a plant pathogenic fungus.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Uncovering the Host Range-Lifestyle Relationship in the Endophytic and Anthracnose Pathogenic GenusMicroorganisms · 2025Review
- Discovering the hidden function in fungal genomes.Nature communications · 2024Review
- Optimizing bacteriophage treatment of resistantmSphere · 2024Article
- Article
- Fungal Pathogenesis-Related Cell Wall Biogenesis, with Emphasis on the Maize Anthracnose FungusPlants (Basel, Switzerland) · 2022Review
- Proteinaceous Effector Discovery and Characterization in Plant PathogenicFrontiers in microbiology · 2022Review
- Comparative Genomics and Gene Pool Analysis Reveal the Decrease of Genome Diversity and Gene Number in Rice Blast Fungi by Stable Adaption with Rice.Journal of fungi (Basel, Switzerland) · 2021Article
- Divergence of a genomic island leads to the evolution of melanization in a halophyte root fungus.The ISME journal · 2021Article
- Peroxiredoxin alleviates the fitness costs of imidacloprid resistance in an insect pest of rice.PLoS biology · 2021Article
- Mosaicism in Human Health and Disease.Annual review of genetics · 2020Review
- Article
- Gene cluster conservation provides insight into cercosporin biosynthesis and extends production to the genusProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Mind the gap! The mitochondrial control region and its power as a phylogenetic marker in echinoids.BMC evolutionary biology · 2018Article
- Intraspecific comparative genomics of isolates of the Norway spruce pathogen (Heterobasidion parviporum) and identification of its potential virulence factors.BMC genomics · 2018Article
- Ceratocystis cacaofunesta genome analysis reveals a large expansion of extracellular phosphatidylinositol-specific phospholipase-C genes (PI-PLC).BMC genomics · 2018Article
- EumicrobeDBLite: a lightweight genomic resource and analytic platform for draft oomycete genomes.Molecular plant pathology · 2018Article
- A comparative genomic analysis of putative pathogenicity genes in the host-specific sibling species Colletotrichum graminicola and Colletotrichum sublineola.BMC genomics · 2017Article
- A highly conserved metalloprotease effector enhances virulence in the maize anthracnose fungus Colletotrichum graminicola.Molecular plant pathology · 2016Article
- Genus-Wide Comparative Genome Analyses of Colletotrichum Species Reveal Specific Gene Family Losses and Gains during Adaptation to Specific Infection Lifestyles.Genome biology and evolution · 2016Article
- Comparative Genomic Analysis among Four Representative Isolates ofFrontiers in microbiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural selection leaves imprints on DNA, offering the opportunity to identify functionally important regions of the genome. Identifying the genomic regions affected by natural selection within pathogens can aid in the pursuit of effective strategies to control diseases. In this study, we analyzed genome-wide patterns of selection acting on different classes of sequences in a worldwide sample of eight strains of the model plant-pathogenic fungus Colletotrichum graminicola. We found evidence of selective sweeps, balancing selection, and positive selection affecting both protein-coding and noncoding DNA of pathogenicity-related sequences. Genes encoding putative effector proteins and secondary metabolite biosynthetic enzymes show evidence of positive selection acting on the coding sequence, consistent with an Arms Race model of evolution. The 5' untranslated regions (UTRs) of genes coding for effector proteins and genes upregulated during infection show an excess of high-frequency polymorphisms likely the consequence of balancing selection and consistent with the Red Queen hypothesis of evolution acting on these putative regulatory sequences. Based on the findings of this work, we propose that even though adaptive substitutions on coding sequences are important for proteins that interact directly with the host, polymorphisms in the regulatory sequences may confer flexibility of gene expression in the virulence processes of this important plant pathogen.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.