ReviewJournal of the Royal Society of Medicine2014
Mechanisms and management of functional abdominal pain.
Review in Journal of the Royal Society of Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Paradigm Shift of Microbiota-gut-brain Axis During Aging: Potential Role of Probiotics to Improve Cognitive Decline.Probiotics and antimicrobial proteins · 2026Review
- Frequency and predictors of fructose malabsorption in patients with functional abdominal pain syndrome: A case-control study.World journal of gastrointestinal pathophysiology · 2026Article
- Transcutaneous Vagal Nerve Stimulation for Gastrointestinal Disorders.Journal of translational gastroenterology · 2025Article
- Electroacupuncture at ST36 Alleviates Visceral Hypersensitivity and Anxiety via ACC-AIC Circuit Modulation in IBS Rats.Neuropsychiatric disease and treatment · 2025Article
- Understanding functional abdominal pain disorders among children: a multidisciplinary expert consensus statement.Frontiers in pediatrics · 2025Review
- The Latest Data Concerning the Etiology and Pathogenesis of Irritable Bowel Syndrome.Journal of clinical medicine · 2024Review
- Gut Microbiota and Aging: Traditional Chinese Medicine and Modern Medicine.Clinical interventions in aging · 2023Review
- Randomized clinical trial: the effects of pregabalin for centrally mediated abdominal pain syndrome.Therapeutic advances in gastroenterology · 2023Article
- Quantitative Assessment of Secondary Healthcare Utilisation by Patients With Functional Abdominal Pain.Cureus · 2022Article
- Microbiota in health and diseases.Signal transduction and targeted therapy · 2022Review
- Acupuncture as Part of Multimodal Analgesia for Chronic Pain.Orthopedic reviews · 2022Article
- [Centrally Mediated Abdominal Pain Syndrome].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2021Review
- Behavioral Intervention in Children with Functional Abdominal Pain Disorders: A Promising Option.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021Article
- Comparison of child abuse history in patients with and without functional abdominal pain: a case-control study.BMC psychiatry · 2020Article
- Critical evaluation of animal models of visceral pain for therapeutics development: A focus on irritable bowel syndrome.Neurogastroenterology and motility · 2020Review
- An approach to the care of patients with irritable bowel syndrome.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020Review
- Irritable Bowel Syndrome between Molecular Approach and Clinical Expertise-Searching for Gap Fillers in the Oxidative Stress Way of Thinking.Medicina (Kaunas, Lithuania) · 2020Review
- Underlying molecular and cellular mechanisms in childhood irritable bowel syndrome.Molecular and cellular pediatrics · 2016Article
- Common Functional Gastroenterological Disorders Associated With Abdominal Pain.Mayo Clinic proceedings · 2016Review
- A Review of Select Centralized Pain Syndromes: Relationship With Childhood Sexual Abuse, Opiate Prescribing, and Treatment Implications for the Primary Care Physician.Health services research and managerial epidemiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Functional abdominal pain syndrome is characterised by frequent or continuous abdominal pain associated with a degree of loss of daily activity. It has a reported population prevalence of between 0.5% and 1.7%, with a female preponderance. The pathophysiology of functional abdominal pain is incompletely understood although it has been postulated that peripheral sensitisation of visceral afferents, central sensitisation of the spinal dorsal horn and aberrancies within descending modulatory systems may have an important role. The management of patients with functional abdominal pain requires a tailored multidisciplinary approach in a supportive and empathetic environment in order to develop an effective therapeutic relationship. Patient education directed towards an explanation of the pathophysiology of functional abdominal pain is in our opinion a prerequisite step and provides the rationale for the introduction of interventions. Interventions can usefully be categorised into general measures, pharmacotherapy, psychological interventions and 'step-up' treatments. Pharmacotherapeutic/step-up options include tricyclic antidepressants, serotonin noradrenergic reuptake inhibitors and the gabapentinoids. Psychological treatments include cognitive behavioural therapy and hypnotherapy. However, the objective evidence base for these interventions is largely derived from other chronic pain syndrome, and further research is warranted in adult patients with functional abdominal pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.