Evidence map›Paper›PMID 25193002›Full record

Trial reportBehaviour research and therapy2014

Impact of cognitive-behavioral therapy for social anxiety disorder on the neural bases of emotional reactivity to and regulation of social evaluation.

Philippe R Goldin, Michal Ziv, Hooria Jazaieri, Justin Weeks, Richard G Heimberg, James J Gross

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Behaviour research and therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00380731 (fMRI of Emotional Reactivity Cognitive Regulation and CBT for Social Phobia), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00380731 nacompletednot on this map

fMRI of Emotional Reactivity Cognitive Regulation and CBT for Social Phobia

TypeinterventionalSponsorStanford UniversityRan2006 to 2011Enrolled124ConditionsSocial PhobiaArmsIndividual Cognitive Behavioral Therapy
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Does non-invasive brain stimulation modulate emotional stress reactivity?Social cognitive and affective neuroscience · 2020
    Pooled it
  3. Pooled it
  4. Trial
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  8. Article
  9. Review
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  14. Neurocircuitry of treatment in anxiety disorders.Biomarkers in neuropsychiatry · 2022
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Philippe R GoldinStanford University, Department of Psychology, Jordan Hall, Stanford, CA 94305, USA. Electronic address: pgoldin@ucdavis.edu.
Michal ZivStanford University, Department of Psychology, Jordan Hall, Stanford, CA 94305, USA.
Hooria JazaieriStanford University, Department of Psychology, Jordan Hall, Stanford, CA 94305, USA.
Justin WeeksOhio University, Department of Psychology, 249 Porter Hall, Athens, OH 45701, USA.
Richard G HeimbergTemple University, Department of Psychology, Weiss Hall, 1701 North 13th Street, Philadelphia, PA 19122, USA.
James J GrossStanford University, Department of Psychology, Jordan Hall, Stanford, CA 94305, USA.

Funding

X-RAY COMPATIBLE RF-COIL FOR MR IMAGINGP41RR009784 · NCRR · STANFORD UNIVERSITY · PI GLOVER, GARY H · 1995 to 2011
$15.0M
fMRI of Emotional Reactivity, Cognitive Regulation, and CBT for Social PhobiaR01MH076074 · NIMH · STANFORD UNIVERSITY · PI GROSS, JAMES J · 2006 to 2010
$2.0M
NCRR NIH HHS P41 RR009784NIMH NIH HHS R01 MH076074
6 · The paper itself

Abstract

We examined whether Cognitive-Behavioral Therapy (CBT) for social anxiety disorder (SAD) would modify self-reported negative emotion and functional magnetic resonance imaging brain responses when reacting to and reappraising social evaluation, and tested whether changes would predict treatment outcome in 59 patients with SAD who completed CBT or waitlist groups. For reactivity, compared to waitlist, CBT resulted in (a) increased brain responses in right superior frontal gyrus (SFG), inferior parietal lobule (IPL), and middle occipital gyrus (MOG) when reacting to social praise, and (b) increases in right SFG and IPL and decreases in left posterior superior temporal gyrus (pSTG) when reacting to social criticism. For reappraisal, compared to waitlist, CBT resulted in greater (c) reductions in self-reported negative emotion, and (d) increases in brain responses in right SFG and MOG, and decreases in left pSTG. A linear regression found that after controlling for CBT-induced changes in reactivity and reappraisal negative emotion ratings and brain changes in reactivity to praise and criticism, reappraisal of criticism brain response changes predicted 24% of the unique variance in CBT-related reductions in social anxiety. Thus, one mechanism underlying CBT for SAD may be changes in reappraisal-related brain responses to social criticism. CLINICALTRIALSGOV IDENTIFIER: NCT00380731. http://www.clinicaltrials.gov/ct2/show/NCT00380731?term=social+anxiety+cognitive+behavioral+therapy+Stanford&rank=1.

Indexed as

Social BehaviorAdultAnxietyBrainCognitive Behavioral TherapyEmotionsFemaleHumansMagnetic Resonance ImagingMalePhobic DisordersTreatment OutcomeYoung AdultCognitive-behavioral therapyEmotionEmotion regulationNeuroimagingReappraisalSocial anxiety

Identifiers

PMID25193002
PMCPMC4253719

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.