SynthesisFamily practice2014
Multi-drug therapy in chronic condition multimorbidity: a systematic review.
Synthesis in Family practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 74 citations in OpenAlex.
- Development and Validation of a Nomogram to Predict the Risk of Potentially Inappropriate Medication Use in Older Outpatients with Depression.Journal of clinical medicine · 2026Article
- Prevalence and impact of non-prescription medication misuse in the geriatric population.Exploratory research in clinical and social pharmacy · 2025Article
- Impact of multimorbidity on health-related quality of life: the mediation role of intrinsic capacity - evidence from the WHO ICOPE pilot program in Lianyungang of China (2024).Archives of public health = Archives belges de sante publique · 2025Article
- iSIMPATHY: a multinational pre-post non-randomised intervention study transforming medication review.BMJ open · 2025Article
- Article
- Analysis of current status and influencing factors of participation in medication safety behaviors among older adult patients with chronic co-morbidities: based on the COM-B model.Frontiers in public health · 2025Article
- A randomized controlled trial of acupuncture and receptive music therapy for sleep disorders in the elderly-ELAMUS: study protocol.BMC complementary medicine and therapies · 2024Article
- Trends in the Prevalence of Multiple Chronic Conditions Among US Adults With Hypertension From 1999-2000 Through 2017-2020.American journal of hypertension · 2024Article
- The prevalence and severity of upper gastrointestinal complications among patients with chronic diseases: a cross-sectional study from Palestine.BMC gastroenterology · 2024Article
- Antidepressant treatment and mortality in people with comorbid depression and type 2 diabetes: UK electronic health record study.BJPsych open · 2024Article
- Synergistic Effects of Caffeine in Combination with Conventional Drugs: Perspectives of a Drug That Never Ages.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Over the Counter Pain Medications Used by Adults: A Need for Pharmacist Intervention.International journal of environmental research and public health · 2023Article
- Interactions of alcohol and combination antiretroviral (cART) drug in diabetic male Sprague Dawley rats: Hippocampal perturbations and toxicosis.Toxicology reports · 2023Article
- Preferences for pharmacogenomic testing in polypharmacy patients: a discrete choice experiment.Personalized medicine · 2022Article
- Phytotherapeutic Approaches to the Prevention of Age-Related Changes and the Extension of Active Longevity.Molecules (Basel, Switzerland) · 2022Review
- An Atypical Case of Extreme Polypharmacy.Drug, healthcare and patient safety · 2022Article
- Multimorbidity in the Elderly: A Systematic Bibliometric Analysis of Research Output.International journal of environmental research and public health · 2021Review
- Chronic diseases in the geriatric population: morbidity and use of primary care services according to risk level.BMC geriatrics · 2021Observational
- Synergistic Effect of Barbadensis miller and Marsdenia Condurango Extracts Induces Apoptosis Promotes Oxidative Stress by Limiting Proliferation of Cervical Cancer and Liver Cancer Cells.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOlder populations often suffer from multimorbidity and guidelines for each condition are often associated with recommended drug therapy management. Yet, how different and specific multimorbidity is associated with number and type of multi-drug therapies in general populations is unknown.
aimThe aim of this systematic review was to synthesize the current evidence on patterns of multi-drug prescribing in family practice.
methodsA systematic review on six common chronic conditions: diabetes mellitus, cardiovascular disease, cerebrovascular disease, chronic obstructive pulmonary disease (COPD), osteoarthritis and depression was conducted, with a focus on studies which looked at any potential combination of two or more multimorbidity. Studies were identified from searches of MEDLINE, EMBASE, PsychINFO, the Allied and Complementary Medicine Database (AMED) and the Health Management Information Consortium (HMIC) databases from 1960 to 2013.
resultsA total of eleven articles were selected based on study criteria. Our review identified very few specific studies which had explicitly investigated the association between multimorbidity and multi-drug therapy. Relevant chronic conditions literature showed nine observational studies and two reviews of comorbid depression drug treatment. Most (seven) of the articles had focused on the chronic condition and comorbid depression and whether antidepressant management had been optimal or not, while four studies focused on other multimorbidities mainly heart failure, COPD and diabetes.
conclusionsVery few studies have investigated associations between specific multimorbidity and multi-drug therapy, and most currently focus on chronic disease comorbid depression outcomes. Further research needs to identify this area as key priority for older populations who are prescribed high levels of multiple drug therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.