ArticleJournal of dental research2014
Development of an antibacterial root canal filling system containing MDPB.
Article in Journal of dental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Analysis of fracture resistance in teeth obturated with graphene oxide-modified sealers.Bioinformation · 2025Article
- Effect of Antibacterial Root Canal Sealer on Persistent Apical Periodontitis.Antibiotics (Basel, Switzerland) · 2021Article
- Article
- Bibliometric Analysis of Literature Published on Antibacterial Dental Adhesive from 1996-2020.Polymers · 2020Review
- Emerging Contact-Killing Antibacterial Strategies for Developing Anti-Biofilm Dental Polymeric Restorative Materials.Bioengineering (Basel, Switzerland) · 2020Review
- Novel Bioactive and Therapeutic Root Canal Sealers with Antibacterial and Remineralization Properties.Materials (Basel, Switzerland) · 2020Review
- Anti-biofilm activity of a novel pit and fissure self-adhesive sealant modified with metallic monomers.Biofouling · 2020Article
- A novel antibacterial resin-based root canal sealer modified by Dimethylaminododecyl Methacrylate.Scientific reports · 2019Article
- Novel Approaches to the Control of Oral Microbial Biofilms.BioMed research international · 2018Review
- Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance.Progress in polymer science · 2017Review
- Innovative root-end filling materials based on calcium-silicates and calcium-phosphates.Journal of materials science. Materials in medicine · 2017Article
- Effect of bioactive dental adhesive on periodontal and endodontic pathogens.Journal of materials science. Materials in medicine · 2016Article
- Methacryloxylethyl Cetyl Ammonium Chloride Induces DNA Damage and Apoptosis in Human Dental Pulp Cells via Generation of Oxidative Stress.International journal of biological sciences · 2016Article
- N-Acetyl Cysteine (NAC)-Directed Detoxification of Methacryloxylethyl Cetyl Ammonium Chloride (DMAE-CB).PloS one · 2015Article
- Novel biomaterials and technologies for the dental, oral, and craniofacial structures.Journal of dental research · 2014Article
- A new improved protocol for in vitro intratubular dentinal bacterial contamination for antimicrobial endodontic tests: standardization and validation by confocal laser scanning microscopy.Journal of applied oral science : revista FOBArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An antibacterial monomer 12-methacryloyloxydodecylpyridinum bromide (MDPB)-containing experimental, chemically cured primer was prepared to develop a new resin-based root canal filling system. This study investigated the antibacterial effects of the MDPB-containing primer (experimental primer [EP]) against Enterococcus faecalis and assessed the in vitro bonding and sealing abilities of the filling system, consisting of EP and a Bis-GMA-based sealer resin. Antibacterial effects of EP were evaluated by contact with planktonic or adherent bacteria for 30 or 60 sec, and the viable bacterial number was counted. The antibacterial effects against E. faecalis in dentinal tubules were also assessed, according to a root canal infection model. Bonding and sealing abilities of the experimental filling system were examined by microtensile bond strength tests and leakage tests based on fluid filtration methods. Significantly greater reduction in viable bacteria in planktonic and adherent form was obtained by short-period contact with EP compared with the control primer (without MDPB) or with the proprietary (Epiphany) primer (p < .05). Significantly greater bactericidal effects of the EP inside the dentinal tubule of root, as opposed to the control primer or Epiphany primer, were confirmed according to a root canal infection model (p < .05), and 100% killing of E. faecalis could be obtained by the application of EP after irrigation with a 5% sodium hypochlorite solution. The experimental endodontic filling system demonstrated significantly greater bond strength to root dentin than Epiphany sealer system (Epiphany primer and Epiphany Root Canal Sealant; p < .05), showing formation of resin tags and a hybridized layer. Leakage tests clarified that the experimental system provided excellent sealing. This study confirmed that the MDPB-containing experimental antibacterial primer has the ability to effectively disinfect the root canal. Additionally, the experimental root canal filling system employing this primer and the Bis-GMA-based sealer resin is useful for achieving good sealing, suggesting its possible benefit for successful endodontic treatments.
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