Evidence map›Paper›PMID 25192820›Full record

ArticleNitric oxide : biology and chemistry2014

Analysis of the HNO and NO donating properties of alicyclic amine diazeniumdiolates.

Gaurav Bharadwaj, Patricia G Z Benini, Debashree Basudhar, Cyf N Ramos-Colon, Gail M Johnson, Marti M Larriva, Larry K Keefer, Daniela Andrei, Katrina M Miranda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nitric oxide : biology and chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 24 citations in OpenAlex.

  1. Kinetic Study on the Reactivity of Azanone (HNO) toward CyclicInternational journal of molecular sciences · 2021
    Article
  2. Review
  3. Biological signaling by small inorganic molecules.Coordination chemistry reviews · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Gaurav BharadwajDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, USA.
Patricia G Z BeniniDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, USA.
Debashree BasudharDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, USA.
Cyf N Ramos-ColonDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, USA.
Gail M JohnsonDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, USA.
Marti M LarrivaDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, USA.
Larry K KeeferChemical Biology Laboratory, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA.
Daniela AndreiChemical Biology Laboratory, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA.
Katrina M MirandaDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, USA. Electronic address: kmiranda@email.arizona.edu.
University of Arizona · USFrederick National Laboratory for Cancer Research · US

Funding

Using Diazeniumdiolate Chemistry to Design Nitric Oxide-Based TherapiesZIABC005673 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KEEFER, LARRY K · 2009 to 2015
$5.5M
Assessment of the Chemical Biology of HNO via New DonorsR01GM076247 · NIGMS · UNIVERSITY OF ARIZONA · PI MIRANDA, KATRINA M. · 2006 to 2010
$1.1M
Intramural NIH HHSNIGMS NIH HHS R01 GM076247NIGMS NIH HHS R01-GM076247
6 · The paper itself

Abstract

Nitroxyl (HNO) donors have been shown to elicit a variety of pharmacological responses, ranging from tumoricidal effects to treatment of heart failure. Isopropylamine-based diazeniumdiolates have been shown to produce HNO on decomposition under physiological conditions. Herein, we report the synthesis and HNO release profiles of primary alicyclic amine-based diazeniumdiolates. These compounds extend the range of known diazeniumdiolate-based HNO donors. Acetoxymethyl ester-protected diazeniumdiolates were also synthesized to improve purification and cellular uptake. The acetoxymethyl derivative of cyclopentylamine diazeniumdiolate not only showed higher cytotoxicity toward cancer cells as compared to the parent anion but was also effective in combination with tamoxifen for targeting estrogen receptor α-negative breast cancer cells.

Indexed as

Azo CompoundsMagnetic Resonance SpectroscopyNitric OxideSpectrophotometry, UltravioletAzo CompoundsdiazeniumdiolateNitric OxideAngeli's saltDiazeniumdiolateIPA/NONitric oxideNitroxylTamoxifen

Identifiers

PMID25192820
PMCPMC4258449
OpenAlexW2021724708

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.