ArticleNeuroImage2014
Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo.
Article in NeuroImage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Blood flow analysis of retinal neovascularisations in a VLDLR mouse model using contrast-enhanced optical coherence tomography.Biomedical optics express · 2026Article
- Bessel beam optical coherence microscopy enables multiscale assessment of cerebrovascular network morphology and function.Light, science & applications · 2024Article
- Neurovascular effects of cocaine: relevance to addiction.Frontiers in pharmacology · 2024Review
- Advanced high resolution three-dimensional imaging to visualize the cerebral neurovascular network in stroke.International journal of biological sciences · 2022Review
- High-resolution, depth-resolved vascular leakage measurements using contrast-enhanced, correlation-gated optical coherence tomography in mice.Biomedical optics express · 2021Article
- Validation of red blood cell flux and velocity estimations based on optical coherence tomography intensity fluctuations.Scientific reports · 2020Article
- A deep-learning-based approach for noise reduction in high-speed optical coherence Doppler tomography.Journal of biophotonics · 2020Article
- Visibility of microvessels in Optical Coherence Tomography angiography depends on angular orientation.Journal of biophotonics · 2020Article
- Longitudinal in-vivo OCM imaging of glioblastoma development in the mouse brain.Biomedical optics express · 2020Article
- Methylene blue-filled biodegradable polymer particles as a contrast agent for optical coherence tomography.Biomedical optics express · 2020Article
- In vivo detection of tumor boundary using ultrahigh-resolution optical coherence angiography and fluorescence imaging.Journal of biophotonics · 2020Article
- Photoacoustic imaging of living mice enhanced with a low-cost contrast agent.Biomedical optics express · 2019Article
- Spatio-temporal dynamics of cerebral capillary segments with stalling red blood cells.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Normalized field autocorrelation function-based optical coherence tomography three-dimensional angiography.Journal of biomedical optics · 2019Article
- MRI techniques to measure arterial and venous cerebral blood volume.NeuroImage · 2019Review
- Synchronized Astrocytic CaCell reports · 2018Article
- Enhancement of morphological and vascular features in OCT images using a modified Bayesian residual transform.Biomedical optics express · 2018Article
- Investigation of artifacts in retinal and choroidal OCT angiography with a contrast agent.Biomedical optics express · 2018Article
- Can OCT Angiography Be Made a Quantitative Blood Measurement Tool?Applied sciences (Basel, Switzerland) · 2017Article
- Volumetric Doppler angle correction for ultrahigh-resolution optical coherence Doppler tomography.Applied physics letters · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Despite widespread applications of multiphoton microscopy in microcirculation, its small field of view and inability to instantaneously quantify cerebral blood flow velocity (CBFv) in vascular networks limit its utility in investigating the heterogeneous responses to brain stimulations. Optical Doppler tomography (ODT) provides 3D images of CBFv networks, but it suffers poor sensitivity for measuring capillary flows. Here we report on a new method, contrast-enhanced ODT with Intralipid that significantly improves quantitative CBFv imaging of capillary networks by obviating the errors from long latency between flowing red blood cells (low hematocrit ~20% in capillaries). This enhanced sensitivity allowed us to measure the ultraslow microcirculation surrounding a brain tumor and the abnormal ingrowth of capillary flows in the tumor as well as in ischemia triggered by chronic cocaine in the mouse brain that could not be detected by regular ODT. It also enabled significantly enhanced sensitivity for quantifying the heterogeneous CBFv responses of vascular networks to acute cocaine exposure. Inasmuch as lipid emulsions are widely used for parenteral nutrition the Intralipid contrast method has translational potential for clinical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.