Evidence map›Paper›PMID 25192616›Full record

ReviewMayo Clinic proceedings2014

Evaluation and management of patients with heart disease and cancer: cardio-oncology.

Joerg Herrmann, Amir Lerman, Nicole P Sandhu, Hector R Villarraga, Sharon L Mulvagh, Manish Kohli

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Mayo Clinic proceedings, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03694262 (An Open Label, Non-Randomized Multisite Phase II Trial Combining Bevacizumab, Atezolizumab and Rucaparib for the Treatment of Previously Treated Recurrent and Progressive Endometrial Carcinoma), which is not on this map. Cited by 188 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
188citing papers in PubMed, 3 pooled it
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03694262 phase2completednot on this mapstarted 2019, after this paper: background citation

An Open Label, Non-Randomized Multisite Phase II Trial Combining Bevacizumab, Atezolizumab and Rucaparib for the Treatment of Previously Treated Recurrent and Progressive Endometrial Carcinoma

TypeinterventionalSponsorMedical College of WisconsinRan2019 to 2026Enrolled30ConditionsEndometrial Cancer, Uterine CarcinosarcomaArmsRucaparib, Bevacizumab, Atezolizumab
3 · Its place in the literature

Who cites it

188 citing papers in PubMed, 3 syntheses or guidelines pooled it, 416 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Evaluating the role of survivorship care plans in modifying disparities in health status among female cancer survivors in Maryland.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
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  13. Observational
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  20. Cardio-Oncology and Multi-Imaging Modalities.Journal of clinical medicine · 2025
    Review

128 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joerg HerrmannDepartment of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN. Electronic address: herrmann.joerg@mayo.edu.
Amir LermanDepartment of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.
Nicole P SandhuDivision of General Internal Medicine, Mayo Clinic, Rochester, MN.
Hector R VillarragaDepartment of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.
Sharon L MulvaghDepartment of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.
Manish KohliDepartment of Oncology, Mayo Clinic, Rochester, MN.
Mayo Clinic in Arizona · USWinnMed · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
The pathophysiological role of the immunoproteasome in atherosclerosisK08HL116952 · NHLBI · MAYO CLINIC ROCHESTER · PI HERRMANN, JOERG · 2014 to 2018
$750k
NCATS NIH HHS UL1 TR000135NHLBI NIH HHS K08 HL116952
6 · The paper itself

Abstract

The care for patients with cancer has advanced greatly over the past decades. A combination of earlier cancer diagnosis and greater use of traditional and new systemic treatments has decreased cancer-related mortality. Effective cancer therapies, however, can result in short- and long-term comorbidities that can decrease the net clinical gain by affecting quality of life and survival. In particular, cardiovascular complications of cancer treatments can have a profound effect on the health of patients with cancer and are more common among those with recognized or unrecognized underlying cardiovascular diseases. A new discipline termed cardio-oncology has thus evolved to address the cardiovascular needs of patients with cancer and optimize their care in a multidisciplinary approach. This review provides a brief introduction and background on this emerging field and then focuses on its practical aspects including cardiovascular risk assessment and prevention before cancer treatment, cardiovascular surveillance and therapy during cancer treatment, and cardiovascular monitoring and management after cancer therapy. The content of this review is based on a literature search of PubMed between January 1, 1960, and February 1, 2014, using the search terms cancer, cardiomyopathy, cardiotoxicity, cardio-oncology, chemotherapy, heart failure, and radiation.

Indexed as

Antineoplastic AgentsHeart DiseasesHumansNeoplasmsRisk AssessmentAntineoplastic Agents

Identifiers

PMID25192616
PMCPMC4258909
OpenAlexW2123380464

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.