ArticleGut2015
Intergenerational reduction in Helicobacter pylori prevalence is similar between different ethnic groups living in a Western city.
Article in Gut, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The Effects of Synbiotic "Canadian journal of gastroenterology & hepatology · 2017Trial
- Generational immigration status and gastric cancer incidence among Japanese descendants: an analysis of the Multiethnic Cohort (MEC) Study.Cancer causes & control : CCC · 2026Article
- Determinants ofBMJ open · 2026Article
- Prevalence of Helicobacter pylori infection in the general population in Wuzhou, China: a cross-sectional study.Infectious agents and cancer · 2025Article
- Changing prevalence of Helicobacter pylori infection in children and adolescents.Clinical and experimental pediatrics · 2021Article
- When is Helicobacter pylori acquired in populations in developing countries? A birth-cohort study in Bangladeshi children.Gut microbes · 2018Article
- Review
- Helicobacter pylori colonization and obesity - a Mendelian randomization study.Scientific reports · 2017Article
- Article
- Helicobacter pylori in children with asthmatic conditions at school age, and their mothers.Alimentary pharmacology & therapeutics · 2016Article
- The Generation R Study: Biobank update 2015.European journal of epidemiology · 2014Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveHelicobacter pylori colonisation rates in childhood have declined in Western populations, but it is unknown whether this trend is similar in children of non-Western ethnic backgrounds, born in a Western country. We aimed to identify H. pylori status in children, and determine mother-to-child transmission and risk factors for colonisation.
designAntibodies against H. pylori and cytotoxin-associated gene A (CagA) were measured in children participating in a population-based prospective cohort study in Rotterdam, the Netherlands. Information on demographics and characteristics was collected using questionnaires.
resultsWe analysed the serum of 4467 children (mean age 6.2 years±0.4 SD) and compared the results with the H. pylori status of their mothers (available for 3185 children). Overall, 438 (10%) children were H. pylori-positive, of whom 142 (32%) were CagA-positive. Independent risk factors for colonisation were: maternal H. pylori positivity (OR 2.12; 95% CI 1.62 to 2.77), non-Dutch ethnicity (OR 2.05; 95% CI 1.54 to 2.73), female gender (OR 1.47; 95% CI 1.20 to 1.80) and lower maternal education level (OR 1.38; 95% CI 1.06 to 1.79). Comparing mothers and children, we found an intergenerational decrease of 76% and 77% for Hp(+)CagA(-) and Hp(+)CagA(+)-strains, respectively, consistent across all nine ethnic groups studied. Male gender, higher maternal educational level and no older siblings, were independently associated with absence of H. pylori.
conclusionsAlthough the highest H. pylori and CagA prevalence was found in children of non-Dutch ethnicities, the decreased colonisation rates were uniform across all ethnic groups, implying the importance of environmental factors in H. pylori transmission in modern cities, independent of ethnicity.
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