ArticleAmerican journal of respiratory and critical care medicine2014
Multicenter study comparing case definitions used to identify patients with chronic obstructive pulmonary disease.
Article in American journal of respiratory and critical care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03137303 (Reducing Diagnostic Error to Improve Patient Safety in COPD and Asthma), which is not on this map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reducing Diagnostic Error to Improve Patient Safety in COPD and Asthma (REDEFINE Study)
Who cites it
32 citing papers in PubMed.
- PhenoFit: a framework for determining computable phenotyping algorithm fitness for purpose and reuse.Journal of the American Medical Informatics Association : JAMIA · 2026Article
- Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants.Genome biology · 2026Article
- Improving Pulmonary Rehabilitation Participation: It's Time to Examine the System.Annals of the American Thoracic Society · 2024Article
- Article
- Clarifying Chronic Obstructive Pulmonary Disease Genetic Associations Observed in Biobanks via Mediation Analysis of Smoking.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2024Article
- Revealing polygenic pleiotropy using genetic risk scores for asthma.HGG advances · 2023Article
- How Important is Spirometry for Identifying Patients with COPD Appropriate for Palliative Care?Journal of pain and symptom management · 2023Article
- Care Quality for Patients with Chronic Obstructive Pulmonary Disease in the Readmission Penalty Era.American journal of respiratory and critical care medicine · 2023Article
- Outcomes of Patients with COPD Hospitalized for Coronavirus Disease 2019.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2021Article
- Artificial Intelligence and Machine Learning in Chronic Airway Diseases: Focus on Asthma and Chronic Obstructive Pulmonary Disease.International journal of medical sciences · 2021Review
- Informing Healthcare Decisions with Observational Research Assessing Causal Effect. An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2021Article
- Factors Associated with Differential Readmission Diagnoses Following Acute Exacerbations of Chronic Obstructive Pulmonary Disease.Journal of hospital medicine · 2020Article
- Trait Insights Gained by Comparing Genome-Wide Association Study Results using Different Chronic Obstructive Pulmonary Disease Definitions.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2020Article
- Electronic Medical Record Inaccuracies: Multicenter Analysis of Challenges with Modified Lung Cancer Screening Criteria.Canadian respiratory journal · 2020Article
- Article
- Poor Metered-Dose Inhaler Technique Is Associated with Overuse of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease.Annals of the American Thoracic Society · 2019Article
- Accuracy of electronic health record data for the diagnosis of chronic obstructive pulmonary disease in persons living with HIV and uninfected persons.Pharmacoepidemiology and drug safety · 2019Article
- The Impact of Care Specialty on Survival-Adjusted Medical Costs of COPD Patients After a Hospitalization: a longitudinal analysis.Journal of general internal medicine · 2018Article
- Sleep Disturbance in Smokers with Preserved Pulmonary Function and with Chronic Obstructive Pulmonary Disease.Annals of the American Thoracic Society · 2017Article
- Spirometry is not enough to diagnose COPD in epidemiological studies: a follow-up study.NPJ primary care respiratory medicine · 2017Article
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Authors and funding
14 authors.
Funding
Abstract
rationaleClinical trials in chronic obstructive pulmonary disease (COPD) usually require evidence of airflow obstruction and clinical risk factors. International Classification of Diseases, Ninth Revision (ICD-9) diagnosis codes or patient-reported physician diagnoses are often used for epidemiologic studies and performance improvement programs.
objectivesTo evaluate agreement between these case definitions for COPD and to assess the comparability of study populations identified as having COPD not using the clinical trial reference standard.
methodsWe recruited patients from the COPD Outcomes-based Network for Clinical Effectiveness and Research Translation multicenter clinical registry in a cross-sectional study. Demographics, clinical, and post-bronchodilator spirometry data were collected at an in-person study visit. The kappa statistic (κ) was used to evaluate agreement. A multivariable logistic regression model was used to identify patient characteristics associated with meeting the trial reference standard. MEASUREMENTS AND MAIN
resultsA total of 998 (82.8%) of 1,206 study participants met at least one case definition for COPD (of the 998: 91% using ICD-9 codes, 73% using patient-reported physician diagnosis, 56% using trial reference standard); agreement between case definitions was poor (κ = 0.20-0.26). Lack of airflow obstruction was the principal (89%) reason patients identified as having COPD did not meet the trial reference standard. Patients who were black (vs. white), obese (vs. normal weight), or had depression (vs. not) were less likely to meet the trial reference standard (odds ratio [95% CI], 0.37 [0.26-0.53], 0.51 [0.34-0.75], 0.53 [0.40-0.71], respectively).
conclusionsFindings highlight concerns about the applicability of findings in clinical trials to patients meeting other case definitions for COPD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.