ArticleActa orthopaedica2015
iNOS expression and osteocyte apoptosis in idiopathic, non-traumatic osteonecrosis.
Article in Acta orthopaedica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 0 citations in OpenAlex.
- Role of Non-Coding RNAs in Pathogenesis, Diagnosis, and Therapy of Legg-Calvé-Perthes Disease: A Systematic Review.Medical science monitor : international medical journal of experimental and clinical research · 2025Pooled it
- Local delivery of gaseous signaling molecules for orthopedic disease therapy.Journal of nanobiotechnology · 2023Review
- Connection between Osteoarthritis and Nitric Oxide: From Pathophysiology to Therapeutic Target.Molecules (Basel, Switzerland) · 2023Review
- Autologous Marrow Mesenchymal Stem Cell Driving Bone Regeneration in a Rabbit Model of Femoral Head Osteonecrosis.Pharmaceutics · 2022Article
- Association of Nitric Oxide Synthase Polymorphism and Coagulopathy in Patients with Osteonecrosis of the Femoral Head.Journal of clinical medicine · 2022Article
- New Insight on the Immune Modulation and Physical Barrier Protection Caused by Vitamin A in Fish Gills Infected WithFrontiers in immunology · 2022Article
- Glucocorticoid-induced osteonecrosis in systemic lupus erythematosus patients.Clinical and translational medicine · 2021Review
- Systems analysis of avascular necrosis of femoral head using integrative data analysis and literature mining delineates pathways associated with disease.Scientific reports · 2020Article
- Aminoguanidine inhibits IL-1β-induced protein expression of iNOS and COX-2 by blocking the NF-κB signaling pathway in rat articular chondrocytes.Experimental and therapeutic medicine · 2020Article
- Association of reduced sclerostin expression with collapse process in patients with osteonecrosis of the femoral head.International orthopaedics · 2018Article
- Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis.Molecular medicine reports · 2018Article
- Vertebral bone microarchitecture and osteocyte characteristics of three toothed whale species with varying diving behaviour.Scientific reports · 2017Article
- Region specific Raman spectroscopy analysis of the femoral head reveals that trabecular bone is unlikely to contribute to non-traumatic osteonecrosis.Scientific reports · 2017Article
- Avascular Necrosis of the Femoral Head: Are Any Genes Involved?The archives of bone and joint surgery · 2015Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeNon-traumatic osteonecrosis is a progressive disease with multiple etiologies. It affects younger individuals more and more, often leading to total hip arthroplasty. We investigated whether there is a correlation between inducible nitric oxide synthase (iNOS) expression and osteocyte apoptosis in non-traumatic osteonecrosis. PATIENTS AND
methodsWe collected and studied 20 human idiopathic, non-traumatic osteonecrosis femoral heads. Subchondral bone samples in the non-sclerotic region (n = 30), collected from osteoarthritis patients, were used as controls. Spontaneously hypertensive rats were used as a model for osteonecrosis in the study. We used scanning electron microscopy, TUNEL assay, and immunohistochemical staining to study osteocyte changes and apoptosis.
resultsThe morphology of osteocytes in the areas close to the necrotic region changed and the number of apoptotic osteocytes increased in comparison with the same region in control groups. The expression of iNOS and cytochrome C in osteocytes increased while Bax expression was not detectable in osteonecrosis samples. Using spontaneously hypertensive rats, we found a positive correlation between iNOS expression and osteocyte apoptosis in the osteonecrotic region. iNOS inhibitor (aminoguanidine) added to the drinking water for 5 weeks reduced the production of iNOS and osteonecrosis compared to a control group without aminoguanidine.
interpretationOur findings show that increased iNOS expression can lead to osteocyte apopotosis in idiopathic, non-traumatic osteonecrosis and that an iNOS inhibitor may prevent the progression of the disease.
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