Evidence map›Paper›PMID 25191578›Full record

ArticleJournal of nutritional science2013

Effect of supplementation with vitamin D2-enhanced mushrooms on vitamin D status in healthy adults.

Magdalena Stepien, Louise O'Mahony, Aifric O'Sullivan, John Collier, William D Fraser, Michael J Gibney, Anne P Nugent, Lorraine Brennan

Open access · goldAbstract read
In one paragraph

Article in Journal of nutritional science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 49 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Content of Vitamin DMetabolites · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Safety of vitamin DEFSA journal. European Food Safety Authority · 2024
    Article
  9. Review
  10. Review
  11. A Randomized Controlled Trial onAntioxidants (Basel, Switzerland) · 2022
    Article
  12. Safety of vitamin DEFSA journal. European Food Safety Authority · 2022
    Article
  13. Effects of Dietary Supplementation with Mushroom or Vitamin DAnimals : an open access journal from MDPI · 2021
    Article
  14. Review
  15. Safety of Vitamin DEFSA journal. European Food Safety Authority · 2021
    Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Magdalena StepienUCD Institute of Food and Health, University College Dublin , Belfield, Dublin 4 , Republic of Ireland ; UCD Conway Institute, University College Dublin , Belfield, Dublin 4 , Republic of Ireland.
Louise O'MahonyUCD Institute of Food and Health, University College Dublin , Belfield, Dublin 4 , Republic of Ireland ; UCD Conway Institute, University College Dublin , Belfield, Dublin 4 , Republic of Ireland.
Aifric O'SullivanUCD Institute of Food and Health, University College Dublin , Belfield, Dublin 4 , Republic of Ireland ; UCD Conway Institute, University College Dublin , Belfield, Dublin 4 , Republic of Ireland.
John CollierMonaghan Mushrooms Ireland , Tyholland, Co. Monaghan , Republic of Ireland.
William D FraserInstitute of Aging and Chronic Disease , Prescot Street, Liverpool L69 3GA , UK.
Michael J GibneyUCD Institute of Food and Health, University College Dublin , Belfield, Dublin 4 , Republic of Ireland.
Anne P NugentUCD Institute of Food and Health, University College Dublin , Belfield, Dublin 4 , Republic of Ireland.
Lorraine BrennanUCD Institute of Food and Health, University College Dublin , Belfield, Dublin 4 , Republic of Ireland ; UCD Conway Institute, University College Dublin , Belfield, Dublin 4 , Republic of Ireland.
University College Dublin · IE

Funding

Medical Research Council G0801462
6 · The paper itself

Abstract

Vitamin D deficiency is emerging worldwide and many studies now suggest its role in the development of several chronic diseases. Due to the low level of vitamin D naturally occurring in food there is a need for supplementation and use of vitamin D-enhanced products. The aim of the present study was to determine if daily consumption of vitamin D2-enhanced mushrooms increased vitamin D status in free-living healthy adults or affected markers of the metabolic syndrome. A total of ninety volunteers (aged 40-65 years) were randomly assigned to one of two 4-week studies: mushroom study (15 µg vitamin D2 or placebo mushroom powder) and capsule study (15 µg vitamin D3 or placebo capsules). Consumption of vitamin D2-enhanced mushrooms increased serum 25-hydroxyvitamin D2 (25(OH)D2) by 128 % from baseline (3·9 (sd 1·9) nmol/l; P < 0·05). Serum 25(OH)D3 increased significantly in the vitamin D3 capsule group (a 55 % increase from a baseline of 44.0 (sd 17·1) nmol/l; P < 0·05). Vitamin D status (25(OH)D) was affected only in the vitamin D3 group. Plasminogen activator inhibitor-1 was lowered by vitamin D2 intake. Vitamin D2 from enhanced mushrooms was bioavailable and increased serum 25(OH)D2 concentration with no significant effect on 25(OH)D3 or total 25(OH)D.

Indexed as

25(OH)D, 25-hydroxyvitamin DFood enhancementhsCRP, high-sensitivity C-reactive proteinMetabolic syndromeMetS, metabolic syndromeMushroomsPAI-1, plasminogen activator inhibitor-1PTH, parathyroid hormoneVitamin D status

Identifiers

PMID25191578
PMCPMC4153019
OpenAlexW2140222583

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.