Evidence map›Paper›PMID 25191546›Full record

ArticleJournal of nutritional science2012

Substitution of TAG oil with diacylglycerol oil in food items improves the predicted 10 years cardiovascular risk score in healthy, overweight subjects.

Vibeke H Telle-Hansen, Ingunn Narverud, Kjetil Retterstøl, Nima Wesseltoft-Rao, Annhild Mosdøl, Linda Granlund, Kirsti Forstrøm Christiansen, Amandine Lamglait, Bente Halvorsen, Kirsten B Holven and 1 more

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In one paragraph

Article in Journal of nutritional science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Trial
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Vibeke H Telle-HansenDepartment of Health, Nutrition and Management , Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences , Post Box 4, St. Olavsplass, 0130 Oslo , Norway ; Department of Nutrition , Institute for Basic Medical Sciences, University of Oslo , Post Box 1046, Blindern, 0317 Oslo , Norway.
Ingunn NarverudDepartment of Health, Nutrition and Management , Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences , Post Box 4, St. Olavsplass, 0130 Oslo , Norway ; Department of Nutrition , Institute for Basic Medical Sciences, University of Oslo , Post Box 1046, Blindern, 0317 Oslo , Norway.
Kjetil RetterstølDepartment of Nutrition , Institute for Basic Medical Sciences, University of Oslo , Post Box 1046, Blindern, 0317 Oslo , Norway ; Lipid Clinic, Medical Department, Rikshospitalet , Oslo University Hospital , Post Box 4950, Nydalen, 0424 Oslo , Norway.
Nima Wesseltoft-RaoDepartment of Health, Nutrition and Management , Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences , Post Box 4, St. Olavsplass, 0130 Oslo , Norway ; Department of Nutrition , Institute for Basic Medical Sciences, University of Oslo , Post Box 1046, Blindern, 0317 Oslo , Norway.
Annhild MosdølDepartment of Health, Nutrition and Management , Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences , Post Box 4, St. Olavsplass, 0130 Oslo , Norway.
Linda GranlundMills DA, Post Box 4644, Sofienberg, 0506 Oslo , Norway.
Kirsti Forstrøm ChristiansenMills DA, Post Box 4644, Sofienberg, 0506 Oslo , Norway.
Amandine LamglaitMills DA, Post Box 4644, Sofienberg, 0506 Oslo , Norway.
Bente HalvorsenResearch Institute for Internal Medicine, Faculty of Medicine, University of Oslo, Rikshospitalet, Oslo University Hospital , Post Box 4950, Nydalen, 0424 Oslo , Norway.
Kirsten B HolvenDepartment of Nutrition , Institute for Basic Medical Sciences, University of Oslo , Post Box 1046, Blindern, 0317 Oslo , Norway.
Stine M UlvenDepartment of Health, Nutrition and Management , Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences , Post Box 4, St. Olavsplass, 0130 Oslo , Norway.
OsloMet – Oslo Metropolitan University · NOPosten (Norway) · NOOslo University Hospital · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary fat is normally in TAG form, but diacylglycerol (DAG) is a natural component of edible oils. Studies have shown that consumption of DAG results in metabolic characteristics that are distinct from those of TAG, which may be beneficial in preventing and managing obesity. The objective of the present study was to investigate if food items in which part of the TAG oil is replaced with DAG oil combined with high α-linolenic acid (ALA) content would influence metabolic markers. A 12-week double-blinded randomised controlled parallel-design study was conducted. The participants (n 23) were healthy, overweight men and women, aged 37-67 years, BMI 27-35 kg/m(2), with waist circumference >94 cm (men) and >88 cm (women). The two groups received 20 g margarine, 11 g mayonnaise and 12 g oil per d, containing either high ALA and sn-1,3-DAG or high ALA and TAG. Substitution of TAG oil with DAG oil in food items for 12 weeks led to an improvement of the predicted 10 years cardiovascular risk score in overweight subjects by non-significantly improving markers of health such as total body fat percentage, trunk fat mass, alanine aminotransferase, systolic blood pressure, γ-glutamyl transferase, alkaline phosphatase and total fat-free mass. This may suggest that replacing TAG oil with DAG oil in healthy, overweight individuals may have beneficial metabolic effects.

Indexed as

ALAT, alanine aminotransferaseALA, α-linolenic acidALP, alkaline phosphataseASAT, aspartame aminotransferaseCRP, C-reactive proteinDAG, diacylglycerolDiacylglycerolFFM, fat-free massHOMA-IR, homeostatic model assessment for insulin resistancehsCRP, high-sensitivity CRPLiver markersOverweight human subjectsTAGγ-GT, γ-glutamyl transferase

Identifiers

PMID25191546
PMCPMC4153080
OpenAlexW2107584201

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.