ArticleJournal of nutritional science2012
Bioavailability of vitamin C from kiwifruit in non-smoking males: determination of 'healthy' and 'optimal' intakes.
Article in Journal of nutritional science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- SunGold Kiwifruit and Psychological Health (GoKiPH): A Randomised Controlled Crossover Trial.Nutrients · 2025Trial
- Intravenous vitamin C administration to patients with septic shock: a pilot randomised controlled trial.Critical care (London, England) · 2022Trial
- The effect of 'Zesy002' kiwifruit (Journal of nutritional science · 2019Trial
- Kiwifruit Exchanges for Increased Nutrient Richness with Little Effect on Carbohydrate Intake, Glycaemic Impact, or Insulin Response.Nutrients · 2018Trial
- Trial
- A randomised cross-over pharmacokinetic bioavailability study of synthetic versus kiwifruit-derived vitamin C.Nutrients · 2013Trial
- A randomized steady-state bioavailability study of synthetic versus natural (kiwifruit-derived) vitamin C.Nutrients · 2013Trial
- Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations.The American journal of clinical nutrition · 2013Trial
- Effects of Green and Gold Kiwifruit Varieties on Antioxidant Neuroprotective Potential in Pigs as a Model for Human Adults.Nutrients · 2024Article
- A High Vitamin C Micronutrient Supplement Is Unable to Attenuate Inflammation in People with Metabolic Syndrome but May Improve Metabolic Health Indices: A Randomised Controlled Trial.Antioxidants (Basel, Switzerland) · 2024Article
- SunGold Kiwifruit Consumption Restores Adequate to Optimal Vitamin C Status in People with a History of Severe Respiratory Infections.Antioxidants (Basel, Switzerland) · 2024Article
- Effects of Low Vitamin C Intake on Fertility Parameters and Pregnancy Outcomes in Guinea Pigs.Nutrients · 2023Article
- Inflammation and Vitamin C in Women with Prenatal Depression and Anxiety: Effect of Multinutrient Supplementation.Antioxidants (Basel, Switzerland) · 2023Article
- Effect of intravenous vitamin C on arterial blood gas analyser and Accu-Chek point-of-care glucose monitoring in critically ill patients.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2022Article
- Habitual Green Kiwifruit Consumption Is Associated with a Reduction in Upper Gastrointestinal Symptoms: A Systematic Scoping Review.Advances in nutrition (Bethesda, Md.) · 2022Article
- Vitamin C Status in People with Types 1 and 2 Diabetes Mellitus and Varying Degrees of Renal Dysfunction: Relationship to Body Weight.Antioxidants (Basel, Switzerland) · 2022Article
- Neutrophils Isolated from Septic Patients Exhibit Elevated Uptake of Vitamin C and Normal Intracellular Concentrations despite a Low Vitamin C Milieu.Antioxidants (Basel, Switzerland) · 2021Article
- Ascorbate Inhibits Proliferation and Promotes Myeloid Differentiation inFrontiers in oncology · 2021Article
- Positive Association of Ascorbate and Inverse Association of Urate with Cognitive Function in People with Parkinson's Disease.Antioxidants (Basel, Switzerland) · 2020Article
- Observational
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin C is an essential nutrient in humans and must be obtained through the diet. The aim of this study was to determine vitamin C uptake in healthy volunteers after consuming kiwifruit (Actinidia chinensis var. Hort. 16A), and to determine the amount of fruit required to raise plasma vitamin C to 'healthy' (i.e. >50 µmol/l) and 'optimal' or saturating levels (i.e. >70 µmol/l). Leucocyte and urinary vitamin C levels were also determined. A total of fifteen male university students with below average levels of plasma vitamin C were selected for the study. Weekly fasting blood samples were obtained for a 4-week lead-in period and following supplementation with, sequentially, half, one, two and three Gold kiwifruit per d for 4-6 weeks each, followed by a final 4-week washout period. The results showed that addition of as little as half a kiwifruit per d resulted in a significant increase in plasma vitamin C. However, one kiwifruit per d was required to reach what is considered healthy levels. Increasing the dose of kiwifruit to two per d resulted in further increases in plasma vitamin C levels as well as increased urinary output of the vitamin, indicating that plasma levels were saturating at this dosage. Dividing the participants into high and low vitamin C groups based on their baseline plasma and leucocyte vitamin C levels demonstrated that it is critical to obtain a study population with low initial levels of the vitamin in order to ascertain a consistent effect of supplementation.
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Registered trials
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