ReviewFrontiers in genetics2014
The use of epigenetic phenomena for the improvement of sheep and cattle.
Review in Frontiers in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Functional studies on methylation of the promoter region of the NR2E1 gene regulating adipocytes in beef cattle.BMC genomics · 2025Article
- Polar Metabolite Profiles Distinguish Between Early and Severe Sub-Maintenance Nutritional States of Wild Bighorn Sheep.Metabolites · 2025Article
- M2 macrophages secrete glutamate-containing extracellular vesicles to alleviate osteoporosis by reshaping osteoclast precursor fate.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- DNA hydroxymethylation differences underlie phenotypic divergence of somatic growth in Nile tilapia reared in common garden.Epigenetics · 2023Article
- Imprinted Dlk1-Gtl2 cluster miRNAs are potential epigenetic regulators of lamb fur quality.BMC genomics · 2023Article
- Effects of DNA Methylation on Gene Expression and Phenotypic Traits in Cattle: A Review.International journal of molecular sciences · 2023Review
- Feedomics provides bidirectional omics strategies between genetics and nutrition for improved production in cattle.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- Variability in Global DNA Methylation Rate Across Tissues and Over Time in Sheep.Frontiers in genetics · 2022Article
- Interplay Between Stress and Reproduction: Novel Epigenetic Markers in Response to Shearing Patterns in Australian Merino Sheep (Frontiers in veterinary science · 2022Article
- DNA methylation studies in cattle.Journal of applied genetics · 2021Review
- Harnessing genomics to fast-track genetic improvement in aquaculture.Nature reviews. Genetics · 2020Review
- Impacts of Epigenetic Processes on the Health and Productivity of Livestock.Frontiers in genetics · 2020Review
- Article
- Rambouillet and Romanov reciprocal breed effects on survival and growth traits of F1 lambs and on reproductive traits of F1 ewes.Journal of animal science · 2019Article
- Identification of bovine CpG SNPs as potential targets for epigenetic regulation via DNA methylation.PloS one · 2019Article
- Intergenerational Transmission of Characters Through Genetics, Epigenetics, Microbiota, and Learning in Livestock.Frontiers in genetics · 2019Review
- Quantitative epigenetics and evolution.Heredity · 2018Review
- Transgenerational epigenetic inheritance in birds.Environmental epigenetics · 2018Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review considers the evidence for inheritance across generations of epigenetic marks and how this phenomenon could be exploited in the cattle and sheep industries. Epigenetic marks are chemical changes in the chromosomes that affect the expression of genes and hence the phenotype of the cell and are passed on during mitosis so that the daughter cells have the same chemical changes or epigenetic marks as the parent cell. Although most epigenetic marks are wiped clean in the process of forming a new zygote, some epigenetic marks (epimutations) may be passed on from parent to offspring. The inheritance of epigenetic marks across generations is difficult to prove as there are usually alternative explanations possible. There are few well documented cases, mainly using inbred strains of mice. The epimutations are unstable and revert to wild type after a few generations. Although, there are no known cases in sheep or cattle, it is likely that inherited epimutations occur in these species but it is unlikely that they explain a large part of the inherited or genetic variation. There is limited evidence in mice and rats that an environmental treatment can cause a change in the epigenetic marks of an animal and that this change can be passed on the next generation. If inherited epimutations occur in sheep and cattle, they will already be utilized to some extent by existing genetic improvement programs. It would be possible to modify the statistical models used in the calculation of estimated breeding values to better recognize the variance controlled by epimutations, but it would probably have, at best, a small effect on the rate on genetic (inherited) gain achieved. Although not a genetic improvement, the inheritance of epigenetic marks caused by the environment experienced by the sire offers a new opportunity in sheep and cattle breeding. However, at present we do not know if this occurs or, if it does, what environmental treatment might have a beneficial effect.
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Registered trials
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