ReviewFrontiers in immunology2014
Regulatory T-cells in pregnancy: historical perspective, state of the art, and burning questions.
Review in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed.
- Peripheral Regulatory T Cells Display Dynamic Memory Subset Frequency and Inhibitory Marker Expression Across Pregnancy.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Article
- Circulating Naïve Regulatory T Cell Subset Displaying Increased STAT5 Phosphorylation During Controlled Ovarian Hyperstimulation Is Associated with Clinical Pregnancy and Progesterone Levels.International journal of molecular sciences · 2026Observational
- CD38+ NK cells: novel players in immunoregulation.Frontiers in immunology · 2026Review
- The role of dendritic cells in recurrent pregnancy loss.Immunologic research · 2025Review
- Inflammatory markers in pregnancy - identifying drivers in four large cohorts.Frontiers in immunology · 2025Article
- Comparing surface immune markers in successful and non-viable ART pregnancies on the day of hCG measurement: a prospective pilot study.Reproduction & fertility · 2025Article
- Dynamics ofIndian journal of microbiology · 2023Article
- Recurrent Abortion and the Involvement of Killer-Cell Immunoglobulin-like Receptor (KIR) Genes, Activated T Cells, NK Abnormalities, and Cytokine Profiles.Journal of clinical medicine · 2023Review
- Article
- Preterm Labor, a Syndrome Attributed to the Combination of External and Internal Factors.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2022Review
- Successful pregnancy and fetal outcome following previous treatment with pembrolizumab for relapsed Hodgkin's lymphoma.Cancer reports (Hoboken, N.J.) · 2022Article
- Effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: It's complicated.Frontiers in immunology · 2022Review
- The Tsallis generalized entropy enhances the interpretation of transcriptomics datasets.PloS one · 2022Article
- Utero-Placental Immune Milieu during Normal and Aglepristone-Induced Parturition in the Dog.Animals : an open access journal from MDPI · 2021Article
- Advances in Hepatitis E Virus Biology and Pathogenesis.Viruses · 2021Review
- Maternal, Decidual, and Neonatal Lymphocyte Composition Is Affected in Pregnant Kidney Transplant Recipients.Frontiers in immunology · 2021Article
- DNA Methylation and Recurrent Pregnancy Loss: A Mysterious Compass?Frontiers in immunology · 2021Review
- Critical Role of the Maternal Immune System in the Pathogenesis of Autism Spectrum Disorder.Biomedicines · 2020Review
- Investigation of the PD-1 and PD-L1 Immune Checkpoint Molecules Throughout Healthy Human Pregnancy and in Nonpregnant Women.Journal of clinical medicine · 2020Article
- Insight Into TLR4-Mediated Immunomodulation in Normal Pregnancy and Related Disorders.Frontiers in immunology · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this review, we first revisit the original concept of "suppressor T-cells" in pregnancy, put it in a historical perspective, and then highlight the main data that licensed its resurrection and revision into the concept of "regulatory T-cells" (Tregs) in pregnancy. We review the evidence for a major role of Tregs in murine and human pregnancy and discuss Treg interactions with dendritic and uterine natural killer cells, other players of maternal-fetal tolerance. Finally, we highlight what we consider as the most important questions in the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.