ReviewFrontiers in pharmacology2014
The role of iron in neurodegenerative disorders: insights and opportunities with synchrotron light.
Review in Frontiers in pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- A Hierarchical Etched Grid for Correlative Chemical Imaging.Chemical & biomedical imaging · 2026Article
- Review
- Label-Free In Situ Chemical Characterization of Amyloid Plaques in Human Brain Tissues.ACS chemical neuroscience · 2024Article
- Dysregulation of Neuronal Iron in Alzheimer's Disease.Current neuropharmacology · 2023Article
- X-ray fluorescence microscopy methods for biological tissues.Metallomics : integrated biometal science · 2022Review
- Biogenic metallic elements in the human brain?Science advances · 2021Article
- Direct measurements of ferric reductase activity of human 101F6 and its enhancement upon reconstitution into phospholipid bilayer nanodisc.Biochemistry and biophysics reports · 2020Article
- Active compounds of herbs ameliorate impaired cognition in APP/PS1 mouse model of Alzheimer's disease.Aging · 2019Article
- Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies.Cells · 2019Article
- Metal Ion Binding to the Amyloid β Monomer Studied by Native Top-Down FTICR Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2019Article
- Mapping Chemical Elements and Iron Oxidation States in the Substantia Nigra of 6-Hydroxydopamine Lesioned Rats Using Correlative Immunohistochemistry With Proton and Synchrotron Micro-Analysis.Frontiers in neuroscience · 2019Article
- No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases.Biological reviews of the Cambridge Philosophical Society · 2018Review
- X-ray fluorescence imaging of metals and metalloids in biological systems.American journal of nuclear medicine and molecular imaging · 2018Review
- Structural basis for promotion of duodenal iron absorption by enteric ferric reductase with ascorbate.Communications biology · 2018Article
- Iron and Alzheimer's Disease: From Pathogenesis to Therapeutic Implications.Frontiers in neuroscience · 2018Review
- Physiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans.International journal of nanomedicine · 2017Review
- Iron Homeostasis in Health and Disease.International journal of molecular sciences · 2016Review
- Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is evidence for iron dysregulation in many forms of disease, including a broad spectrum of neurodegenerative disorders. In order to advance our understanding of the pathophysiological role of iron, it is helpful to be able to determine in detail the distribution of iron as it relates to metabolites, proteins, cells, and tissues, the chemical state and local environment of iron, and its relationship with other metal elements. Synchrotron light sources, providing primarily X-ray beams accompanied by access to longer wavelengths such as infra-red, are an outstanding tool for multi-modal non-destructive analysis of iron in these systems. The micro- and nano-focused X-ray beams that are generated at synchrotron facilities enable measurement of iron and other transition metal elements to be performed with outstanding analytic sensitivity and specificity. Recent developments have increased the scope for methods such as X-ray fluorescence mapping to be used quantitatively rather than semi-quantitatively. Burgeoning interest, coupled with technical advances and beamline development at synchrotron facilities, has led to substantial improvements in resources and methodologies in the field over the past decade. In this paper we will consider how the field has evolved with regard to the study of iron in proteins, cells, and brain tissue, and identify challenges in sample preparation and analysis. Selected examples will be used to illustrate the contribution, and future potential, of synchrotron X-ray analysis for the characterization of iron in model systems exhibiting iron dysregulation, and for human cases of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, Friedreich's ataxia, and amyotrophic lateral sclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.