ArticleFrontiers in computational neuroscience2014
Intracellular calcium dynamics permit a Purkinje neuron model to perform toggle and gain computations upon its inputs.
Article in Frontiers in computational neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Altered motor coordination, vocal communication, and cerebellar circuit connectivity in mice carrying a near-complete human chromosome 21.Translational psychiatry · 2025Article
- Trisomy 21 Alters Motor Coordination, Vocal Communication, and Cerebellar Circuit Connectivity in the TcMAC21 Mouse.Research square · 2025Article
- Study on the Effect of the Envelope of Terahertz Unipolar Stimulation on Cell Membrane Communication-Related Variables.Research (Washington, D.C.) · 2025Article
- Branch-specific clustered parallel fiber input controls dendritic computation in Purkinje cells.iScience · 2024Article
- Purkinje cell models: past, present and future.Frontiers in computational neuroscience · 2024Review
- Radiofrequency electromagnetic field affects heart rate variability in rabbits.Physiological research · 2020Article
- Neural Signals in Red Nucleus during Reactive and Proactive Adjustments in Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Tactile sensory coding and learning with bio-inspired optoelectronic spiking afferent nerves.Nature communications · 2020Article
- Complex Spike Wars: a New Hope.Cerebellum (London, England) · 2018Review
- Aberrant cerebellar Purkinje cell function repaired in vivo by fusion with infiltrating bone marrow-derived cells.Acta neuropathologica · 2018Article
- The relationship between nernst equilibrium variability and the multifractality of interspike intervals in the hippocampus.Journal of computational neuroscience · 2017Article
- Climbing Fibers Control Purkinje Cell Representations of Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Cell type-specific transcriptome profiling in mammalian brains.Frontiers in bioscience (Landmark edition) · 2016Review
- Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times faster.BMC neuroscience · 2015Article
- Bursting regimes in a reaction-diffusion system with action potential-dependent equilibrium.PloS one · 2015Article
- The sodium-potassium pump is an information processing element in brain computation.Frontiers in physiology · 2014Article
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Abstract
Without synaptic input, Purkinje neurons can spontaneously fire in a repeating trimodal pattern that consists of tonic spiking, bursting and quiescence. Climbing fiber input (CF) switches Purkinje neurons out of the trimodal firing pattern and toggles them between a tonic firing and a quiescent state, while setting the gain of their response to Parallel Fiber (PF) input. The basis to this transition is unclear. We investigate it using a biophysical Purkinje cell model under conditions of CF and PF input. The model can replicate these toggle and gain functions, dependent upon a novel account of intracellular calcium dynamics that we hypothesize to be applicable in real Purkinje cells.
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