Evidence map›Paper›PMID 25191250›Full record

ArticleFrontiers in human neuroscience2014

The development of an RDoC-based treatment program for adolescent depression: "Training for Awareness, Resilience, and Action" (TARA).

Eva Henje Blom, Larissa G Duncan, Tiffany C Ho, Colm G Connolly, Kaja Z LeWinn, Margaret Chesney, Frederick M Hecht, Tony T Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
  4. Pooled it
  5. Trial
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  7. Review
  8. Dealing with overwhelming life situations - young people's experiences of becoming depressed.Scandinavian journal of child and adolescent psychiatry and psychology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eva Henje BlomDepartment of Clinical Neuroscience, Karolinska Institutet Stockholm, Sweden ; Department of Psychiatry, Division of Child and Adolescent Psychiatry, University of California San Francisco San Francisco, CA, USA.
Larissa G DuncanDepartment of Family and Community Medicine, University of California San Francisco San Francisco, CA, USA ; Osher Center for Integrative Medicine, University of California San Francisco San Francisco, CA, USA.
Tiffany C HoDepartment of Psychiatry, Division of Child and Adolescent Psychiatry, University of California San Francisco San Francisco, CA, USA.
Colm G ConnollyDepartment of Psychiatry, Division of Child and Adolescent Psychiatry, University of California San Francisco San Francisco, CA, USA.
Kaja Z LeWinnDepartment of Psychiatry, Division of Child and Adolescent Psychiatry, University of California San Francisco San Francisco, CA, USA.
Margaret ChesneyOsher Center for Integrative Medicine, University of California San Francisco San Francisco, CA, USA ; Department of Medicine, University of California San Francisco San Francisco, CA, USA.
Frederick M HechtOsher Center for Integrative Medicine, University of California San Francisco San Francisco, CA, USA ; Department of Medicine, University of California San Francisco San Francisco, CA, USA.
Tony T YangDepartment of Psychiatry, Division of Child and Adolescent Psychiatry, University of California San Francisco San Francisco, CA, USA.

Funding

Metabolic and Immunologic Effects of Meditation - Cell Aging SupplementP01AT005013 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HECHT, FREDERICK M · 2008 to 2012
$6.8M
A Cross-Sectional and Longitudinal Functional MRI Study of Adolescent DepressionR01MH085734 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YANG, TONY TUNG-I · 2010 to 2014
$2.7M
A New Translational Tool for Studying the Role of Breathing in Meditation.R01AT005820 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHESNEY, MARGARET ANN · 2009 to 2016
$2.2M
Mentoring and Research in Integrative MedicineK24AT007827 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HECHT, FREDERICK M · 2013 to 2022
$1.8M
Social engagement, emotion regulation and depressive symptoms during adolescenceK01MH097978 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEWINN, KAJA ZABRINA · 2012 to 2015
$749k
Integrative Stress Reduction for Maternal-Child HealthK01AT005270 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUNCAN, LARISSA G · 2009 to 2013
$639k
NCCIH NIH HHS K01 AT005270NCCIH NIH HHS K24 AT007827NCCIH NIH HHS P01 AT005013NCCIH NIH HHS R01 AT005820NIMH NIH HHS K01 MH097978NIMH NIH HHS R01 MH085734
6 · The paper itself

Abstract

Major depressive disorder (MDD) is one of the current leading causes of disability worldwide. Adolescence is a vulnerable period for the onset of depression, with MDD affecting 8-20% of all youth. Traditional treatment methods have not been sufficiently effective to slow the increasing prevalence of adolescent depression. We therefore propose a new model for the treatment of adolescent depression - Training for Awareness, Resilience, and Action (TARA) - that is based on current understanding of developmental and depression neurobiology. The TARA model is aligned with the Research Domain Criteria (RDoC) of the National Institute of Mental Health. In this article, we first address the relevance of RDoC to adolescent depression. Second, we identify the major RDoC domains of function involved in adolescent depression and organize them in a way that gives priority to domains thought to be driving the psychopathology. Third, we select therapeutic training strategies for TARA based on current scientific evidence of efficacy for the prioritized domains of function in a manner that maximizes time, resources, and feasibility. The TARA model takes into consideration the developmental limitation in top-down cognitive control in adolescence and promotes bottom-up strategies such as vagal afference to decrease limbic hyperactivation and its secondary effects. The program has been informed by mindfulness-based therapy and yoga, as well as modern psychotherapeutic techniques. The treatment program is semi-manualized, progressive, and applied in a module-based approach designed for a group setting that is to be conducted one session per week for 12 weeks. We hope that this work may form the basis for a novel and more effective treatment strategy for adolescent depression, as well as broaden the discussion on how to address this challenge.

Indexed as

adolescent depressionattention trainingemotion regulationmindfulnessRDoCtreatment developmentyoga-based movement

Identifiers

PMID25191250
PMCPMC4137278

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.