ArticleThe Yale journal of biology and medicine2014
Arterial shear stress reduces eph-b4 expression in adult human veins.
Article in The Yale journal of biology and medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Changes in vascular identity during vascular remodeling.JVS-vascular science · 2025Article
- Role of endothelial PDGFB in arterio-venous malformations pathogenesis.Angiogenesis · 2024Article
- Direct male development in chromosomally ZZ zebrafish.Frontiers in cell and developmental biology · 2024Article
- Activation of EphrinB2 Signaling Promotes Adaptive Venous Remodeling in Murine Arteriovenous Fistulae.The Journal of surgical research · 2021Article
- Sex Differences in Inflammation During Venous Remodeling of Arteriovenous Fistulae.Frontiers in cardiovascular medicine · 2021Review
- Ephs and Ephrins in Adult Endothelial Biology.International journal of molecular sciences · 2020Review
- Molecular identity of arteries, veins, and lymphatics.Journal of vascular surgery · 2019Review
- NOTCH regulation of the endothelial cell phenotype.Current opinion in hematology · 2018Review
- Mechanotransduction in Coronary Vein Graft Disease.Frontiers in cardiovascular medicine · 2018Article
- Polyester vascular patches acquire arterial or venous identity depending on their environment.Journal of biomedical materials research. Part A · 2017Article
- Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency.Scientific reports · 2017Article
- Improving the Outcome of Vein Grafts: Should Vascular Surgeons Turn Veins into Arteries?Annals of vascular diseases · 2017Review
- Membrane-mediated regulation of vascular identity.Birth defects research. Part C, Embryo today : reviews · 2016Review
- Ephrin type-B receptor 4 activation reduces neointimal hyperplasia in human saphenous vein in vitro.Journal of vascular surgery · 2016Article
- Autologous tissue patches acquire vascular identity depending on the environment.Vascular investigation and therapyArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Vein graft adaptation to the arterial environment is characterized by loss of venous identity, with reduced Ephrin type-B receptor 4 (Eph-B4) expression but without increased Ephrin-B2 expression. We examined changes of vessel identity of human saphenous veins in a flow circuit in which shear stress could be precisely controlled. Medium circulated at arterial or venous magnitudes of laminar shear stress for 24 hours; histologic, protein, and RNA analyses of vein segments were performed. Vein endothelium remained viable and functional, with platelet endothelial cell adhesion molecule (PECAM)-expressing cells on the luminal surface. Venous Eph-B4 expression diminished (p = .002), Ephrin-B2 expression was not induced (p = .268), and expression of osteopontin (p = .002) was increased with exposure to arterial magnitudes of shear stress. Similar changes were not found in veins placed under venous flow or static conditions. These data show that human saphenous veins remain viable during ex vivo application of shear stress in a bioreactor, without loss of the venous endothelium. Arterial magnitudes of shear stress cause loss of venous identity without gain of arterial identity in human veins perfused ex vivo. Shear stress alone, without immunologic or hormonal influence, is capable of inducing changes in vessel identity and, specifically, loss of venous identity.
Indexed as
Identifiers
25191151PMC4144290W121295938What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.