ArticleContemporary clinical dentistry2014
Determination of the antibacterial activity of simvastatin against periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans: An in vitro study.
Article in Contemporary clinical dentistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.The Cochrane database of systematic reviews · 2022Pooled it
- Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.The Cochrane database of systematic reviews · 2019Pooled it
- Periodontal therapy for the management of cardiovascular disease in patients with chronic periodontitis.The Cochrane database of systematic reviews · 2017Pooled it
- Does short preoperative statin therapy prevent infectious complications in adults undergoing cardiac or non-cardiac surgery? A meta-analysis of 5 randomized placebo-controlled trials.Saudi medical journal · 2016Pooled it
- Comparative efficacy of locally delivered 1.2% rosuvastatin and 1.2% simvastatin gel as an adjunct to non-surgical periodontal therapy in chronic periodontitis: a clinical and microbiological assay.The Saudi dental journal · 2026Article
- Comparison of the Antimicrobial Effect of Atorvastatin and Nano-Atorvastatin Mouthwash onJournal of dentistry (Shiraz, Iran) · 2026Article
- Statins, Allies against Antibiotic Resistance?Current medicinal chemistry · 2025Review
- Biosynthesis and Characterization of Silver Nanoparticles and Simvastatin Association in Titanium Biofilms.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Simvastatin, Its Antimicrobial Activity and Its Prevention of Alzheimer's Disease.Microorganisms · 2024Review
- Effect of atorvastatin gel in non-surgical treatment of peri-implant mucositis: A randomized controlled clinical trial.Journal of advanced periodontology & implant dentistry · 2024Article
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- Effects of metformin on human gingival fibroblasts: an in vitro study.BMC oral health · 2023Article
- Combined Release of Antiseptic and Antibiotic Drugs from Visible Light Polymerized Biodegradable Nanocomposite Hydrogels for Periodontitis Treatment.Pharmaceutics · 2022Article
- Antimicrobial and anti-inflammatory activity of Cystatin C on human gingival fibroblast incubated withPeerJ · 2022Article
- Effect of three intracanal medicaments used in pulp regeneration on the push-out bond strength of mineral trioxide aggregate and calcium-enriched mixture: AnJournal of dental research, dental clinics, dental prospects · 2022Article
- In vitro evaluation of disease-modifying antirheumatic drugs against rheumatoid arthritis associated pathogens of the oral microflora.RMD open · 2021Article
- In Search of Spectroscopic Signatures of Periodontitis: A SERS-Based Magnetomicrofluidic Sensor for Detection ofACS sensors · 2021Article
- Therapeutic effects of antibiotics loaded cellulose nanofiber and κ-carrageenan oligosaccharide composite hydrogels for periodontitis treatment.Scientific reports · 2020Article
- Statins-based prophylactic mouthwash and nasal spray may protect against coronavirus disease 2019.New microbes and new infections · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CONTEXT AND
objectiveStatin treatment, apart from its hypolipidemic action has proven its antimicrobial activity by improving the survival rate of patients with severe systemic bacterial infections. Periodontitis is an inflammatory disorder of tooth supporting structures caused by a group of specific microorganisms. The objective of the present study was to determine the antimicrobial activity of pure simvastatin drug against the primary periodontal pathogens. MATERIALS AND
methodsMinimum inhibitory concentration (MIC) was determined against Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans using serial dilution method.
resultsMIC of simvastatin against P. gingivalis was 2 μg/ml and A. actinomycetemcomitans was found to be <1 μg/ml which requires further dilutions to determine the exact value.
conclusionsData suggests a potent antimicrobial activity of simvastatin against both A. actinomycetemcomitans and P gingivalis. Hence simvastatin can be prescribed as a dual action drug in patients with both hyperlipidemia and periodontal disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.