ArticleJournal of human reproductive sciences2014
Cypermethrin-induced reproductive toxicity in the rat is prevented by resveratrol.
Article in Journal of human reproductive sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.
- Pyrethroids Toxicity to Male Reproductive System and Offspring as a Function of Oxidative Stress Induction: Rodent Studies.Frontiers in endocrinology · 2021Pooled it
- A Review of Traditional Chinese Medicine Formulations and Natural Active Ingredients with Therapeutic Potential for Male Infertility Targeting Oxidative Stress.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Endocrine Disrupting Agents: Toxicological Aspects on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Protective effects of lupeol on pesticides induced testicular and oxidative damage of male rats.Journal of molecular histology · 2025Article
- Diet Coke's chronic daily intake in female albino rats: Biochemical and histopathological effects on certain hematological and reproductive parameters.Open veterinary journal · 2025Article
- Role of nutraceutical against exposure to pesticide residues: power of bioactive compounds.Frontiers in nutrition · 2024Review
- Review
- Palliative Effect of Resveratrol against Nanosized Iron Oxide-Induced Oxidative Stress and Steroidogenesis-Related Genes Dysregulation in Testicular Tissue of Adult Male Rats.International journal of environmental research and public health · 2022Article
- Iprodione and/or chlorpyrifos exposure induced testicular toxicity in adult rats by suppression of steroidogenic genes and SIRT1/TERT/PGC-1α pathway.Environmental science and pollution research international · 2021Article
- Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction.Antioxidants (Basel, Switzerland) · 2021Review
- Safety of high-doseFood science & nutrition · 2021Article
- Testosterone recuperates deteriorated male fertility in cypermethrin intoxicated rats.Toxicological research · 2021Article
- Prophylactic effect of resveratrol and piperine on pristane-induced murine model of lupus-like disease.Inflammopharmacology · 2020Article
- Combinatorial therapeutic effect of resveratrol and piperine on murine model of systemic lupus erythematosus.Inflammopharmacology · 2020Article
- Targeting ERK/COX-2 signaling pathway in permethrin-induced testicular toxicity: a possible modulating effect of matrine.Molecular biology reports · 2020Article
- [Cypermethrin induces cell injury in primary cortical neurons of C57BL/6 mice by inhibiting Nrf2/ARE signaling pathway].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
- Protective effects of resveratrol on biomarkers of oxidative stress, biochemical and histopathological changes induced by sub-chronic oral glyphosate-based herbicide in rats.Toxicology research · 2019Article
- Curcumin and Quercetin Ameliorated Cypermethrin and Deltamethrin-Induced Reproductive System Impairment in Male Wistar Rats by Upregulating The Activity of Pituitary-Gonadal Hormones and Steroidogenic Enzymes.International journal of fertility & sterility · 2018Article
- Effect of gasoline fumes on reproductive function in male albino rats.Environmental science and pollution research international · 2018Article
- Side Effects of Pyrethroid and Supporting Role of Onion in the Male Rat's Spermatogenesis.Chinese medical journal · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe current study was to assess the protective role of resveratrol in cypermethrin-induced reproductive toxicity in male Wistar rats. MATERIALS AND
methodsRats were exposed to cypermethrin (3.83 mg/kg bw) for 14 days. Pre- and post-treatment of resveratrol (20 mg/kg bw for 14 days) was given to cypermethrin exposed rats. At the end of the experiment, rats were sacrificed, testis and epididymis were removed, sperm characteristics, sex hormones, and various biochemical parameters were studied.
resultsCypermethrin exposure resulted in a significant decrease in weight of testis and epididymis, testicular sperm head counts, sperm motility and live sperm counts and increase in sperm abnormalities. Serum testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (LH), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and total protein (TP) content were decreased and lipid peroxidation (LPO) level was increased on cypermethrin exposure. Pre- and post-treatment of resveratrol increased sperm head counts, sperm motility, live sperm counts, T, FSH, LH, GSH, CAT, SOD, GST, GR, GPx and TP contents and decreased LPO. Treatment with resveratrol alone has improved sperm parameters and testicular antioxidant defence system.
conclusionThe study concluded that resveratrol ameliorated cypermethrin-induced testicular damage by reducing oxidative stress and by enhancing the level of sex hormones.
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Registered trials
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