ArticleIndian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India2014
A novel method for blood volume estimation using trivalent chromium in rabbit models.
Article in Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 11 citations in OpenAlex.
- Increasing plasma ketamine concentrations decrease the minimum alveolar concentration of isoflurane in rabbits.Frontiers in veterinary science · 2025Article
- Preclinical evaluation of efficacy and pharmacokinetics of gentamicin containing extracellular-matrix envelope.Pacing and clinical electrophysiology : PACE · 2020Article
- Serial blood volume estimation in rabbits using trivalent chromium - An exploratory study.MethodsX · 2019Article
- Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.The Journal of clinical investigation · 2018Article
- Evans Blue Dye: A Revisit of Its Applications in Biomedicine.Contrast media & molecular imaging · 2018Review
- Characterization of the Rabbit as an In Vitro and In Vivo Model to Assess the Effects of Fibrinogenolytic Activity of Snake Venom on Coagulation.Basic & clinical pharmacology & toxicology · 2018Article
- An innovative approach for serial injection in marginal vein and blood collection from auricular artery in New Zealand white Rabbit.MethodsX · 2017Article
- A Modified Carbon Monoxide Breath Test for Measuring Erythrocyte Lifespan in Small Animals.BioMed research international · 2016Article
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7 authors at 4 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundBlood volume measurement though important in management of critically ill-patients is not routinely estimated in clinical practice owing to labour intensive, intricate and time consuming nature of existing methods.
aimsThe aim was to compare blood volume estimations using trivalent chromium [(51)Cr(III)] and standard Evans blue dye (EBD) method in New Zealand white rabbit models and establish correction-factor (CF). MATERIALS AND
methodsBlood volume estimation in 33 rabbits was carried out using EBD method and concentration determined using spectrophotometric assay followed by blood volume estimation using direct injection of (51)Cr(III). Twenty out of 33 rabbits were used to find CF by dividing blood volume estimation using EBD with blood volume estimation using (51)Cr(III). CF is validated in 13 rabbits by multiplying it with blood volume estimation values obtained using (51)Cr(III).
resultsThe mean circulating blood volume of 33 rabbits using EBD was 142.02 ± 22.77 ml or 65.76 ± 9.31 ml/kg and using (51)Cr(III) was estimated to be 195.66 ± 47.30 ml or 89.81 ± 17.88 ml/kg. The CF was found to be 0.77. The mean blood volume of 13 rabbits measured using EBD was 139.54 ± 27.19 ml or 66.33 ± 8.26 ml/kg and using (51)Cr(III) with CF was 152.73 ± 46.25 ml or 71.87 ± 13.81 ml/kg (P = 0.11).
conclusionsThe estimation of blood volume using (51)Cr(III) was comparable to standard EBD method using CF. With further research in this direction, we envisage human blood volume estimation using (51)Cr(III) to find its application in acute clinical settings.
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