ArticleScience (New York, N.Y.)2014
Comment on "Local impermeant anions establish the neuronal chloride concentration".
Article in Science (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Clarifications regarding bumetanide for neonatal seizures.Epilepsia · 2022Trial
- All-optical reporting of inhibitory receptor driving force in the nervous system.Nature communications · 2024Article
- Mathematical modeling of intracellular osmolarity and cell volume stabilization: The Donnan effect and ion transport.The Journal of general physiology · 2024Article
- Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus.Nature reviews. Neurology · 2022Review
- Article
- Mannitol decreases neocortical epileptiform activity during early brain development via cotransport of chloride and water.Neurobiology of disease · 2019Article
- Evolution of our understanding of cell volume regulation by the pump-leak mechanism.The Journal of general physiology · 2019Review
- The logic of ionic homeostasis: Cations are for voltage, but not for volume.PLoS computational biology · 2019Article
- Article
- Tenuous Inhibitory GABAergic Signaling in the Reticular Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Electrodiffusion phenomena in neuroscience: a neglected companion.Nature reviews. Neuroscience · 2017Review
- Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential.Trends in neurosciences · 2017Review
- Commentary: How Cells Can Control Their Size by Pumping Ions.Frontiers in cell and developmental biology · 2017Article
- How Cells Can Control Their Size by Pumping Ions.Frontiers in cell and developmental biology · 2017Article
- Spines slow down dendritic chloride diffusion and affect short-term ionic plasticity of GABAergic inhibition.Scientific reports · 2016Article
- Glia as drivers of abnormal neuronal activity.Nature neuroscience · 2016Review
- Cation-chloride cotransporters in neuronal development, plasticity and disease.Nature reviews. Neuroscience · 2014Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glykys et al. (Reports, 7 February 2014, p. 670) conclude that, rather than ion transporters, "local impermeant anions establish the neuronal chloride concentration" and thereby determine "the magnitude and direction of GABAAR currents at individual synapses." If this were possible, perpetual ion-motion machines could be constructed. The authors' conclusions conflict with basic thermodynamic principles.
Indexed as
Identifiers
25190787What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.