ArticleReproduction (Cambridge, England)2014
In utero exposure to persistent organochlorine pollutants and reproductive health in the human male.
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In one paragraph
Article in Reproduction (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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18citing papers in PubMed, 2 pooled it
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review of associations of polychlorinated biphenyl (PCB) exposure with declining semen quality in support of the derivation of reference doses for mixture risk assessments.Environmental health : a global access science source · 2022Pooled it
- The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders: a systematic review and meta-analysis.Human reproduction update · 2016Pooled it
- Molecular and Computational Studies Reveal That Per- and Polyfluoroalkyl Substances Can Impair Protamine-DNA Interaction, Potentially Inducing DNA Damage.Biomolecules · 2025Article
- In-Vitro Effects of Perfluorooctanoic Acid on Human Sperm Function: What Are the Clinical Consequences?Journal of clinical medicine · 2024Article
- Response to "Comment on 'Maternal Exposure to Per- and Polyfluoroalkyl Substances (PFAS) and Male Reproductive Function in Young Adulthood: Combined Exposure to Seven PFAS'".Environmental health perspectives · 2023Article
- Developmental Exposure to Endocrine Disrupter DDT Interferes with Age-Related Involution of Thymus.International journal of molecular sciences · 2022Article
- Reproductive Health Risks Associated with Occupational and Environmental Exposure to Pesticides.International journal of environmental research and public health · 2021Review
- Endocrine Disrupting Chemicals and Reproductive Health in Boys and Men.Frontiers in endocrinology · 2021Review
- Article
- On endocrine disruption at the workplace - how to get from suggestive to conclusive evidence?Scandinavian journal of work, environment & health · 2020Article
- The Influence of Persistent Organic Pollutants on Thyroidal, Reproductive and Adrenal Hormones After Bariatric Surgery.Obesity surgery · 2020Article
- Novel text analytics approach to identify relevant literature for human health risk assessments: A pilot study with health effects of in utero exposures.Environment international · 2020Review
- Regional difference in semen quality of young men: a review on the implication of environmental and lifestyle factors during fetal life and adulthood.Basic and clinical andrology · 2020Review
- Fetal Programming of Semen Quality (FEPOS) Cohort - A DNBC Male-Offspring Cohort.Clinical epidemiology · 2020Article
- Employing Dietary Comparators to Perform Risk Assessments for Anti-Androgens Without Using Animal Data.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS).International journal of environmental research and public health · 2018Article
- Exposure to multiple chemicals in a cohort of reproductive-aged Danish women.Environmental research · 2017Article
- DPOAEs in infants developmentally exposed to PCBs show two differently time spaced exposure sensitive windows.Chemosphere · 2016Article
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Authors and funding
11 authors.
Anne VestedDepartment of Occupational MedicineDanish Ramazzini Centre, Aarhus University Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Allé 2 Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, DenmarkDepartment of Public HealthBiostatistics, Bartholins Allé 2 Building 1261, DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of Iceland, Eiríksgata 29, 101 Reykjavík, IcelandDepartment of Environmental HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole Worms Allé 2, build. 1170, 8000 Aarhus C, Denmark anneveed@rm.dk.
Cecilia H Ramlau-HansenDepartment of Occupational MedicineDanish Ramazzini Centre, Aarhus University Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Allé 2 Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, DenmarkDepartment of Public HealthBiostatistics, Bartholins Allé 2 Building 1261, DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of Iceland, Eiríksgata 29, 101 Reykjavík, IcelandDepartment of Environmental HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole Worms Allé 2, build. 1170, 8000 Aarhus C, Denmark Department of Occupational MedicineDanish Ramazzini Centre, Aarhus University Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Allé 2 Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, DenmarkDepartment of Public HealthBiostatistics, Bartholins Allé 2 Building 1261, DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of Iceland, Eiríksgata 29, 101 Reykjavík, IcelandDepartment of Environmental HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole Worms Allé 2, build. 1170, 8000 Aarhus C, Denmark.
Sjurdur F OlsenDepartment of Occupational MedicineDanish Ramazzini Centre, Aarhus University Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Allé 2 Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, DenmarkDepartment of Public HealthBiostatistics, Bartholins Allé 2 Building 1261, DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of Iceland, Eiríksgata 29, 101 Reykjavík, IcelandDepartment of Environmental HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole Worms Allé 2, build. 1170, 8000 Aarhus C, Denmark.
Jens Peter BondeDepartment of Occupational MedicineDanish Ramazzini Centre, Aarhus University Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Allé 2 Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, DenmarkDepartment of Public HealthBiostatistics, Bartholins Allé 2 Building 1261, DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of Iceland, Eiríksgata 29, 101 Reykjavík, IcelandDepartment of Environmental HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole Worms Allé 2, build. 1170, 8000 Aarhus C, Denmark.
Henrik StøvringDepartment of Occupational MedicineDanish Ramazzini Centre, Aarhus University Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Allé 2 Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, DenmarkDepartment of Public HealthBiostatistics, Bartholins Allé 2 Building 1261, DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of Iceland, Eiríksgata 29, 101 Reykjavík, IcelandDepartment of Environmental HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole Worms Allé 2, build. 1170, 8000 Aarhus C, Denmark.
Susanne L KristensenDepartment of Occupational MedicineDanish Ramazzini Centre, Aarhus University Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Allé 2 Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, DenmarkDepartment of Public HealthBiostatistics, Bartholins Allé 2 Building 1261, DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of Iceland, Eiríksgata 29, 101 Reykjavík, IcelandDepartment of Environmental HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole Worms Allé 2, build. 1170, 8000 Aarhus C, Denmark.
Thorhallur I HalldorssonDepartment of Occupational MedicineDanish Ramazzini Centre, Aarhus University Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Allé 2 Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, DenmarkDepartment of Public HealthBiostatistics, Bartholins Allé 2 Building 1261, DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of Iceland, Eiríksgata 29, 101 Reykjavík, IcelandDepartment of Environmental HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole Worms Allé 2, build. 1170, 8000 Aarhus C, Denmark Department of Occupational MedicineDanish Ramazzini Centre, Aarhus University Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Allé 2 Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, DenmarkDepartment of Public HealthBiostatistics, Bartholins Allé 2 Building 1261, DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of Iceland, Eiríksgata 29, 101 Reykjavík, IcelandDepartment of Environmental HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole Worms Allé 2, build. 1170, 8000 Aarhus C, Denmark.
Panu RantakokkoDepartment of Occupational MedicineDanish Ramazzini Centre, Aarhus University Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Allé 2 Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, DenmarkDepartment of Public HealthBiostatistics, Bartholins Allé 2 Building 1261, DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of Iceland, Eiríksgata 29, 101 Reykjavík, IcelandDepartment of Environmental HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole Worms Allé 2, build. 1170, 8000 Aarhus C, Denmark.
Hannu KivirantaDepartment of Occupational MedicineDanish Ramazzini Centre, Aarhus University Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Allé 2 Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, DenmarkDepartment of Public HealthBiostatistics, Bartholins Allé 2 Building 1261, DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of Iceland, Eiríksgata 29, 101 Reykjavík, IcelandDepartment of Environmental HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole Worms Allé 2, build. 1170, 8000 Aarhus C, Denmark.
Emil H ErnstDepartment of Occupational MedicineDanish Ramazzini Centre, Aarhus University Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Allé 2 Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, DenmarkDepartment of Public HealthBiostatistics, Bartholins Allé 2 Building 1261, DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of Iceland, Eiríksgata 29, 101 Reykjavík, IcelandDepartment of Environmental HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole Worms Allé 2, build. 1170, 8000 Aarhus C, Denmark.
Gunnar ToftDepartment of Occupational MedicineDanish Ramazzini Centre, Aarhus University Hospital, Noerrebrogade 44 Building 2C, DK-8000 Aarhus C, DenmarkSection for EpidemiologyDepartment of Public Health, University of Aarhus, Bartholins Allé 2 Building 1260, DK-8000 Aarhus C, DenmarkStatens Serum InstitutCentre for Fetal Programming, Artellerivej 5, DK-2300 Copenhagen S, DenmarkDepartment of Occupational and Environmental MedicineBispebjerg Hospital of Copenhagen University, Bispebjerg Bakke 23 Building 33 1st floor, DK-2400 Copenhagen NV, DenmarkDepartment of Public HealthBiostatistics, Bartholins Allé 2 Building 1261, DK-8000 Aarhus C, DenmarkFaculty of Food Science and NutritionUniversity of Iceland, Eiríksgata 29, 101 Reykjavík, IcelandDepartment of Environmental HealthNational Institute for Health and Welfare (THL), PO Box 95, FI-70701 Kuopio, FinlandSection WestInstitute for Biomedicine, Aarhus University, Ole Worms Allé 2, build. 1170, 8000 Aarhus C, Denmark.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent organochlorine pollutants (POPs) are ubiquitous, bioaccumulative compounds with potential endocrine-disrupting effects. They cross the placental barrier thereby resulting in in utero exposure of the developing fetus. The objective of this study was to investigate whether maternal serum concentrations of polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) during pregnancy are associated with son's semen quality and reproductive hormone levels. During 2008-2009, we recruited 176 male offspring from a Danish cohort of pregnant women who participated in a study in 1988-1989. Each provided semen and blood samples that were analyzed for sperm concentration, total sperm count, motility, and morphology, and reproductive hormone levels, respectively. The maternal blood samples were collected in pregnancy week 30 and were analyzed for the concentrations of six PCBs (PCB-118, -138, -153, -156, -170, and -180) and p,p'-DDE. The potential associations between in utero exposure to ΣPCBs (pmol/ml), Σdioxin like-(DL) PCBs (PCB-118 and -156) (pmol/ml), and p,p'-DDE and semen quality and reproductive hormone levels were investigated using multiple regression. Maternal median (range) exposure levels of ΣPCB, ΣDL-PCB, and p,p'-DDE were 10.0 (2.1-35.0) pmol/ml, 0.8 (0.2-2.7) pmol/ml, and 8.0 (0.7-55.3) pmol/ml, respectively, reflecting typical background exposure levels in the late 1980s in Denmark. Results suggested that in utero exposure to ΣPCB, ΣDL-PCB, and p,p'-DDE was not statistically significantly associated with semen quality measures or reproductive hormone levels. Thus, results based on maternal PCB and p,p'-DDE concentrations alone are not indicative of long-term consequences for male reproductive health; however, we cannot exclude that these POPs in concert with other endocrine-modulating compounds may have adverse effects.
Indexed as
Prenatal Exposure Delayed EffectsReproductive HealthSemen AnalysisCohort StudiesDichlorodiphenyl DichloroethyleneEnvironmental PollutantsEstradiolFemaleFollicle Stimulating HormoneHumansHydrocarbons, ChlorinatedLongitudinal StudiesLuteinizing HormoneMalePolychlorinated BiphenylsPregnancyDichlorodiphenyl DichloroethyleneEnvironmental PollutantsEstradiolFollicle Stimulating HormoneHydrocarbons, ChlorinatedLuteinizing HormonePolychlorinated BiphenylsTestosterone
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