Evidence map›Paper›PMID 25190445›Full record

Observational studyStroke2014

Potassium intake and risk of stroke in women with hypertension and nonhypertension in the Women's Health Initiative.

Arjun Seth, Yasmin Mossavar-Rahmani, Victor Kamensky, Brian Silver, Kamakshi Lakshminarayan, Ross Prentice, Linda Van Horn, Sylvia Wassertheil-Smoller

Abstract readObservational Study
In one paragraph

Observational study in Stroke, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Meta-Analysis of Potassium Intake and the Risk of Stroke.Journal of the American Heart Association · 2016
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Association between post-stroke disability and 5-year hip-fracture risk: The Women's Health Initiative.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2020
    Observational
  11. Article
  12. Review
  13. Urinary Potassium Excretion and Progression of CKD.Clinical journal of the American Society of Nephrology : CJASN · 2019
    Observational
  14. Article
  15. Article
  16. Article
  17. Revised Reference Values for Potassium Intake.Annals of nutrition & metabolism · 2017
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Arjun SethFrom the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (A.S., Y.M.-R., V.K., S.W.-S.); Department of Neurology, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence (B.S.); Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (K.L.); Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (R.P.); and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (L.V.H.).
Yasmin Mossavar-RahmaniFrom the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (A.S., Y.M.-R., V.K., S.W.-S.); Department of Neurology, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence (B.S.); Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (K.L.); Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (R.P.); and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (L.V.H.).
Victor KamenskyFrom the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (A.S., Y.M.-R., V.K., S.W.-S.); Department of Neurology, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence (B.S.); Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (K.L.); Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (R.P.); and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (L.V.H.).
Brian SilverFrom the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (A.S., Y.M.-R., V.K., S.W.-S.); Department of Neurology, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence (B.S.); Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (K.L.); Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (R.P.); and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (L.V.H.).
Kamakshi LakshminarayanFrom the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (A.S., Y.M.-R., V.K., S.W.-S.); Department of Neurology, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence (B.S.); Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (K.L.); Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (R.P.); and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (L.V.H.).
Ross PrenticeFrom the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (A.S., Y.M.-R., V.K., S.W.-S.); Department of Neurology, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence (B.S.); Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (K.L.); Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (R.P.); and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (L.V.H.).
Linda Van HornFrom the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (A.S., Y.M.-R., V.K., S.W.-S.); Department of Neurology, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence (B.S.); Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (K.L.); Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (R.P.); and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (L.V.H.).
Sylvia Wassertheil-SmollerFrom the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (A.S., Y.M.-R., V.K., S.W.-S.); Department of Neurology, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence (B.S.); Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (K.L.); Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (R.P.); and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (L.V.H.). Sylvia.smoller@einstein.yu.edu.

Funding

Study of Latinos: Nutrition & Physical Activity Assessment Study (SOLNAS)R01HL095856 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MOSSAVAR-RAHMANI, YASMIN · 2010 to 2013
$3.1M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042119 · WH · YESHIVA UNIVERSITY · PI WASSERTHEIL-SMOLLER, SYLVIA · 1994 to 2001
$2.2M
NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS R01 HL095856NIA NIH HHS HHSN271201100004CWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004CWHI NIH HHS N01 WH042119
6 · The paper itself

Abstract

background and purposeDietary potassium has been associated with lower risk of stroke, but there are little data on dietary potassium effects on different stroke subtypes or in older women with hypertension and nonhypertension.

methodsThe study population consisted of 90 137 postmenopausal women aged 50 to 79 at enrollment, free of stroke history at baseline, followed up prospectively for an average of 11 years. Outcome variables were total, ischemic, and hemorrhagic stroke, and all-cause mortality. Incidence was compared across quartiles of dietary potassium intake, and hazard ratios were obtained from Cox proportional hazards models after adjusting for potential confounding variables, and in women with hypertension and nonhypertension separately.

resultsMean dietary potassium intake was 2611 mg/d. Highest quartile of potassium intake was associated with lower incidence of ischemic and hemorrhagic stroke and total mortality. Multivariate analyses comparing highest to lowest quartile of potassium intake indicated a hazard ratio of 0.90 (95% confidence interval, 0.85-0.95) for all-cause mortality, 0.88 (95% confidence interval, 0.79-0.98) for all stroke, and 0.84 (95% confidence interval, 0.74-0.96) for ischemic stroke. The effect on ischemic stroke was more apparent in women with nonhypertension among whom there was a 27% lower risk with hazard ratio of 0.73 (95% confidence interval, 0.60-0.88), interaction P<0.10. There was no association with hemorrhagic stroke.

conclusionsHigh potassium intake is associated with a lower risk of all stroke and ischemic stroke, as well as all-cause mortality in older women, particularly those who are not hypertensive.

Indexed as

Potassium, DietaryAgedFemaleHumansHypertensionIncidenceMiddle AgedPostmenopauseProportional Hazards ModelsRisk FactorsStrokeWomen's HealthPotassium, Dietarydietaryhypertensionpostmenopausepotassiumstroke

Identifiers

PMID25190445
PMCPMC4175295

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.