ArticleScientific reports2014
Unequivocal identification of intracellular aluminium adjuvant in a monocytic THP-1 cell line.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed.
- Advances on the early cellular events occurring upon exposure of human macrophages to aluminum oxyhydroxide adjuvant.Scientific reports · 2023Article
- Dietary Egg White Hydrolysate Prevents Male Reproductive Dysfunction after Long-Term Exposure to Aluminum in Rats.Metabolites · 2022Article
- Aluminium Nanoparticles as Efficient Adjuvants Compared to Their Microparticle Counterparts: Current Progress and Perspectives.International journal of molecular sciences · 2022Review
- Aluminum-Induced Alterations in Purinergic System Parameters of BV-2 Brain Microglial Cells.Journal of immunology research · 2021Article
- Taphonomic experiments imply a possible link between the evolution of multicellularity and the fossilization potential of soft-bodied organisms.Ecology and evolution · 2021Article
- Unequivocal imaging of aluminium in human cells and tissues by an improved method using morin.Histochemistry and cell biology · 2019Article
- Egg White Hydrolysate as a functional food ingredient to prevent cognitive dysfunction in rats following long-term exposure to aluminum.Scientific reports · 2019Article
- Aluminium in Brain Tissue in Multiple Sclerosis.International journal of environmental research and public health · 2018Article
- Intracellular tracing of amyloid vaccines through direct fluorescent labelling.Scientific reports · 2018Article
- Unraveling the enigma: elucidating the relationship between the physicochemical properties of aluminium-based adjuvants and their immunological mechanisms of action.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2018Review
- Sequestering of damage-associated molecular patterns (DAMPs): a possible mechanism affecting the immune-stimulating properties of aluminium adjuvants.Immunologic research · 2017Article
- Article
- The Identification of Aluminum in Human Brain Tissue Using Lumogallion and Fluorescence Microscopy.Journal of Alzheimer's disease : JAD · 2016Article
- Nanomaterial-Based Vaccine Adjuvants.Journal of materials chemistry. B · 2016Article
- Insight into the cellular fate and toxicity of aluminium adjuvants used in clinically approved human vaccinations.Scientific reports · 2016Article
- Fluorescent nanodiamonds as a relevant tag for the assessment of alum adjuvant particle biodisposition.BMC medicine · 2015Article
- The mechanisms of action of vaccines containing aluminum adjuvants: an in vitro vs in vivo paradigm.SpringerPlus · 2015Article
- Aluminium in Allergies and Allergen immunotherapy.The World Allergy Organization journal · 2015Article
- Polyionic vaccine adjuvants: another look at aluminum salts and polyelectrolytes.Clinical and experimental vaccine research · 2015Review
- Why industry propaganda and political interference cannot disguise the inevitable role played by human exposure to aluminum in neurodegenerative diseases, including Alzheimer's disease.Frontiers in neurology · 2014Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Aluminium-based adjuvants (ABA) are the predominant adjuvants used in human vaccinations. While a consensus is yet to be reached on the aetiology of the biological activities of ABA several studies have identified shape, crystallinity and size as critical factors affecting their adjuvanticity. In spite of recent advances, the fate of ABA following their administration remains unclear. Few if any studies have demonstrated the unequivocal presence of intracellular ABA. Herein we demonstrate for the first time the unequivocal identification of ABA within a monocytic T helper 1 (THP-1) cell line, using lumogallion as a fluorescent molecular probe for aluminium. Use of these new methods revealed that particulate ABA was only found in the cell cytoplasm. Transmission electron microscopy revealed that ABA were contained within vesicle-like structures of approximately 0.5-1 μm in diameter.
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Registered trials
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