ArticleEuropean journal of clinical pharmacology2014
A limited number of prescribed drugs account for the great majority of drug-drug interactions.
Article in European journal of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
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The trial behind it
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Efficacy and Safety of Clopidogrel With and Without a Proton Pump Inhibitor: A Systematic Review and Meta-Analysis.Basic & clinical pharmacology & toxicology · 2025Pooled it
- Drug-drug interaction among elderly patients in Africa: a systematic review and meta-analysis.BMC pharmacology & toxicology · 2025Pooled it
- Prevalence of potential drug‒drug interactions and associated factors among elderly patients in Ethiopia: a systematic review and meta-analysis.Global health research and policy · 2024Pooled it
- Prevalence of drug interactions in hospitalised elderly patients: a systematic review.European journal of hospital pharmacy : science and practice · 2021Pooled it
- A descriptive analysis of drug-drug interactions and corresponding adverse drug reactions in multimorbid older inpatients: findings from the SENATOR trial.European geriatric medicine · 2024Trial
- Assessment of Potential Drug-Drug Interactions and Associated Factors Among Pulmonary Inpatients in a Tertiary Care Hospital: A Cross-Sectional Study.Drugs - real world outcomes · 2026Article
- Prevalence and clinical significance of potential drug-drug interactions of antimicrobials in Intensive Care Unit patients: a retrospective study.BMC pharmacology & toxicology · 2025Article
- Review
- Potential Adverse Drug Events Identified with Decision Support Algorithms from Janusmed Risk Profile-A Retrospective Population-Based Study in a Swedish Region.Pharmacy (Basel, Switzerland) · 2024Article
- Potential Drug-Related Problems in Pediatric Patients-Describing the Use of a Clinical Decision Support System at Pharmacies in Sweden.Pharmacy (Basel, Switzerland) · 2023Article
- Trajectories of medication use and polypharmacy among children with cerebral palsy.Journal of managed care & specialty pharmacy · 2023Article
- Evaluation of Concomitant Use of Anticancer Drugs and Herbal Products: From Interactions to Synergic Activity.Cancers · 2022Article
- Core concepts in pharmacoepidemiology: Measures of drug utilization based on individual-level drug dispensing data.Pharmacoepidemiology and drug safety · 2022Review
- Drug interaction alerts in older primary care patients, and related medically justified actions.European journal of clinical pharmacology · 2022Article
- Determination of potential drug-drug interactions in prescription orders dispensed in a community pharmacy setting using MicromedexInternational journal of clinical pharmacy · 2022Observational
- An Overview of Clinically Imperative and Pharmacodynamically Significant Drug Interactions of Renin-Angiotensin-Aldosterone System (RAAS) Blockers.Current cardiology reviews · 2022Review
- Prevalence of potentially harmful multidrug interactions on medication lists of elderly ambulatory patients.BMC geriatrics · 2021Article
- Prevalence of drug-drug interactions in older people before and after hospital admission: analysis from the OPERAM trial.BMC geriatrics · 2021Article
- Bleeding and thromboembolism due to drug-drug interactions with non-vitamin K antagonist oral anticoagulants-a Swedish, register-based cohort study in atrial fibrillation outpatients.European journal of clinical pharmacology · 2021Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to investigate the prevalence of prescribed combinations of interacting drugs in the Swedish population.
methodsThis study design was retrospective and cross-sectional, based on a national register of dispensed prescription drugs during the period from January 1 to April 30, 2010. Prescription data was linked to the drug-drug interaction database SFINX to yield the prevalence of interacting combinations dispensed in the population. The study focused in particular on C- (clinically relevant interactions that can be handled, e.g. by dose adjustments), and D-interactions (clinically relevant interactions that should be avoided).
resultsThirty-eight and 3.8 % of the population were dispensed combinations of drugs classified as C- or D- interactions, respectively, i.e. clinically relevant, involving all therapeutic areas. Half of the D-interactions were associated with increased risk of adverse drug reactions whereas the other half were considered interactions with a potential to cause therapeutic failure. We identified a top 15 list of D-interactions that included 80 % of the total number of interacting drug combinations. Regarding individual drugs, a group of only ten drugs was involved in as much as 94 % of all D-interactions.
conclusionsThis study reveals that the majority of prescribed interacting drug combinations in Sweden involve a limited number of drugs. The findings may increase the awareness among prescribers of these most common drug interactions in clinical practice and highlight an area for pharmacological education. It may also serve as an inventory of potential interactions within different therapeutic areas for further research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.