ReviewCold Spring Harbor perspectives in medicine2014
Diversity and evolution of Mycobacterium tuberculosis: moving to whole-genome-based approaches.
Review in Cold Spring Harbor perspectives in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Tuberculosis: An Ongoing Global Threat.Advances in experimental medicine and biology · 2026Review
- Real-time PCR assay for robust detection and global surveillance of the Mycobacterium tuberculosis Haarlem genotype.Scientific reports · 2025Article
- Genomic characterization of XDR Mycobacterium tuberculosis isolates in Argentina (2006-2015).BMC infectious diseases · 2025Article
- Genetic diversity and antibiotic resistance ofFrontiers in cellular and infection microbiology · 2025Article
- Single-cell sequencing: Current applications in various tuberculosis specimen types.Cell proliferation · 2024Review
- Review
- Molecular epidemiology and transmission dynamics of multi-drug resistant tuberculosis strains using whole genome sequencing in the Amhara region, Ethiopia.BMC genomics · 2023Article
- Disease phenotypic and geospatial features vary across genetic lineages for Tuberculosis within Arkansas, 2010-2020.PLOS global public health · 2023Article
- Comparative Study on Tuberculosis Drug Resistance and Molecular Detection Methods Among Different Mycobacterium Tuberculosis Lineages.Infection and drug resistance · 2023Article
- Rapid Identification of Drug Resistance and Phylogeny in M. tuberculosis, Directly from Sputum Samples.Microbiology spectrum · 2022Article
- Pan-genome association study ofFrontiers in microbiology · 2022Article
- Survival of hypoxia-induced dormancy is not a common feature of all strains of the Mycobacterium tuberculosis complex.Scientific reports · 2021Article
- Whole Genome Sequencing of Drug Resistant and Drug SusceptibleFrontiers in microbiology · 2021Article
- European Union training programme for tuberculosis laboratory experts: design, contribution and future direction.BMC health services research · 2020Article
- Article
- Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery.Emerging microbes & infections · 2019Review
- Genomic Investigation of aThe American journal of tropical medicine and hygiene · 2018Article
- Harmonized Genome Wide Typing of Tubercle Bacilli Using a Web-Based Gene-By-Gene Nomenclature System.EBioMedicine · 2018Article
- Importance of differential identification of Mycobacterium tuberculosis strains for understanding differences in their prevalence, treatment efficacy, and vaccine development.Journal of microbiology (Seoul, Korea) · 2018Review
- Risk of tuberculosis transmission among healthcare workers.ERJ open research · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genotyping of clinical Mycobacterium tuberculosis complex (MTBC) strains has become a standard tool for epidemiological tracing and for the investigation of the local and global strain population structure. Of special importance is the analysis of the expansion of multidrug (MDR) and extensively drug-resistant (XDR) strains. Classical genotyping and, more recently, whole-genome sequencing have revealed that the strains of the MTBC are more diverse than previously anticipated. Globally, several phylogenetic lineages can be distinguished whose geographical distribution is markedly variable. Strains of particular (sub)lineages, such as Beijing, seem to be more virulent and associated with enhanced resistance levels and fitness, likely fueling their spread in certain world regions. The upcoming generalization of whole-genome sequencing approaches will expectedly provide more comprehensive insights into the molecular and epidemiological mechanisms involved and lead to better diagnostic and therapeutic tools.
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