ArticleBMC infectious diseases2014
Virulence of Legionella pneumophila strains isolated from hospital water system and healthcare-associated Legionnaires' disease in Northern Italy between 2004 and 2009.
Article in BMC infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Environmental Investigations of Travel-Associated Legionnaires' Disease Cases: Timeliness, Microbiological Findings, and Public Health Response.Microorganisms · 2026Article
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- Environmental Monitoring ofInternational journal of environmental research and public health · 2023Article
- Presence of Viable, Clinically RelevantMicrobiology spectrum · 2022Article
- Innovative Antibiofilm Smart Surface againstMicroorganisms · 2022Article
- A Tale of Four Danish Cities:International journal of environmental research and public health · 2022Article
- Review
- Decreasing Pasteurization Treatment Efficiency against Amoeba-GrownInternational journal of environmental research and public health · 2022Article
- Population analysis of Legionella pneumophila reveals a basis for resistance to complement-mediated killing.Nature communications · 2021Article
- Cytotoxicity, Intracellular Replication, and Contact-Dependent Pore Formation of Genotyped EnvironmentalPathogens (Basel, Switzerland) · 2021Article
- Urinary antigene and PCR can both be used to detectEuropean journal of translational myology · 2019Article
- Environmental Surveillance of Legionellosis within an Italian University Hospital-Results of 15 Years of Analysis.International journal of environmental research and public health · 2019Article
- Construction of recombinant Mip-FlaA dominant epitope vaccine against Legionella pneumophila and evaluation of the immunogenicity and protective immunity.Immunologic research · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWorldwide, L. pneumophila sg 1 is the most common agent of Legionnaires' disease ( 80 to 90% of the reported cases). In contrast, L. pneumophila sg 2-14 account for only 15 to 20% of community-acquired cases, although they account for over 50% of the environmental isolates. The discrepancy between environmental isolates and clinical cases of disease suggested that there are differences in virulence.We decided to subtype the environmental Legionella strains isolated from health care facilities (HCFs) and to compare the distribution of strains with the occurrence of hospital-acquired legionellosis.
methodsObservational ecological study based on the data provided by the regional surveillance of legionellosis and on data obtained from hospitals environmental monitoring.Using the monoclonal antibody MAb 3/1 of the Dresden Panel we collected and typed environmental strains of L. pneumophila sg 1 obtained during routine testing in 56 health care facilities from 2004 to 2009.The results of the laboratory analyses of the environmental samples were compared with the number of cases that each health care facility reported during the study period.
resultsThe association between the type of colonisation (L. pneumophila sg 1 vs others serogroups) and the incidence of reported cases was statistically significant (p = 0.03 according to the χ2 test).Legionella strains with the virulence-associated epitope recognised by MAb 3/1 were isolated in 8 of the 26 HCFs colonised by L. pneumophila sg 1; 7 of the HCFs colonised by MAb 3/1-positive strains accounted for 85% of the cases of hospital-acquired legionellosis reported during the 6-year study period. There was a statistically significant association (p = 0.003) between the presence of cases and colonisation by MAb 3/1-positive Legionella strains.
conclusionThis study suggests that hospitals colonised by more virulent strains should be aware of the increased risk and consider the opportunities of increase their monitoring efforts and implement more effective contamination control strategies.
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