SynthesisAJNR. American journal of neuroradiology2015
Meta-analysis of diffusion metrics for the prediction of tumor grade in gliomas.
Synthesis in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Imaging-Based Algorithm for the Local Grading of Glioma.AJNR. American journal of neuroradiology · 2020Trial
- Tensor-Valued Diffusion MRI for Microstructural Assessment During Stereotactic Radiotherapy of Brain Metastases: A Feasibility Study.Tomography (Ann Arbor, Mich.) · 2026Article
- Imaging in Neuro-oncology.Seminars in neurology · 2025Review
- EGFR Amplification in Diffuse Glioma and Its Correlation to Language Tract Integrity.Diagnostics (Basel, Switzerland) · 2025Article
- A multiparametric perspective on C6 and F98 cell lines in orthotopic rat models for glioblastoma research.Scientific reports · 2025Article
- A Longitudinal Multimodal Imaging Study in Patients with Temporo-Insular Diffuse Low-Grade Tumors: How the Inferior Fronto-Occipital Fasciculus Provides Information on Cognitive Outcomes.Current oncology (Toronto, Ont.) · 2024Article
- Article
- Decoding the Heterogeneity of Malignant Gliomas by PET and MRI for Spatial Habitat Analysis of Hypoxia, Perfusion, and Diffusion Imaging: A Preliminary Study.Frontiers in neuroscience · 2022Article
- Article
- MRI biomarkers in neuro-oncology.Nature reviews. Neurology · 2021Review
- Review
- Risk Assessment by Pre-surgical Tractography in Left Hemisphere Low-Grade Gliomas.Frontiers in neurology · 2021Article
- Clinical Management of Diffuse Low-Grade Gliomas.Cancers · 2020Review
- Alterations of white matter integrity associated with cognitive deficits in patients with glioma.Brain and behavior · 2020Article
- Correction to: Advanced imaging in adult diffusely infiltrating low-grade gliomas.Insights into imaging · 2020Article
- Contrahemispheric Cortex Predicts Survival and Molecular Markers in Patients With Unilateral High-Grade Gliomas.Frontiers in oncology · 2020Article
- A simple model for glioma grading based on texture analysis applied to conventional brain MRI.PloS one · 2020Article
- Advanced imaging in adult diffusely infiltrating low-grade gliomas.Insights into imaging · 2019Review
- Apparent diffusion coefficient for molecular subtyping of non-gadolinium-enhancing WHO grade II/III glioma: volumetric segmentation versus two-dimensional region of interest analysis.European radiology · 2018Article
- Machine learning: a useful radiological adjunct in determination of a newly diagnosed glioma's grade and IDH status.Journal of neuro-oncology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeDiffusion tensor metrics are potential in vivo quantitative neuroimaging biomarkers for the characterization of brain tumor subtype. This meta-analysis analyzes the ability of mean diffusivity and fractional anisotropy to distinguish low-grade from high-grade gliomas in the identifiable tumor core and the region of peripheral edema. MATERIALS AND
methodsA meta-analysis of articles with mean diffusivity and fractional anisotropy data for World Health Organization low-grade (I, II) and high-grade (III, IV) gliomas, between 2000 and 2013, was performed. Pooled data were analyzed by using the odds ratio and mean difference. Receiver operating characteristic analysis was performed for patient-level data.
resultsThe minimum mean diffusivity of high-grade gliomas was decreased compared with low-grade gliomas. High-grade gliomas had decreased average mean diffusivity values compared with low-grade gliomas in the tumor core and increased average mean diffusivity values in the peripheral region. High-grade gliomas had increased FA values compared with low-grade gliomas in the tumor core, decreased values in the peripheral region, and a decreased fractional anisotropy difference between the tumor core and peripheral region.
conclusionsThe minimum mean diffusivity differs significantly with respect to the World Health Organization grade of gliomas. Statistically significant effects of tumor grade on average mean diffusivity and fractional anisotropy were observed, supporting the concept that high-grade tumors are more destructive and infiltrative than low-grade tumors. Considerable heterogeneity within the literature may be due to systematic factors in addition to underlying lesion heterogeneity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.