ArticleCell death and differentiation2015
Induction of tissue-specific stem cells by reprogramming factors, and tissue-specific selection.
Article in Cell death and differentiation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Beyond Vision: An Overview of Regenerative Medicine and Its Current Applications in Ophthalmological Care.Cells · 2024Review
- Article
- Recent trends in stem cell-based therapies and applications of artificial intelligence in regenerative medicine.World journal of stem cells · 2021Review
- Induced Tissue-Specific Stem Cells (iTSCs): Their Generation and Possible Use in Regenerative Medicine.Pharmaceutics · 2021Review
- Gene Expression in Pancreatic Cancer-Like Cells and Induced Pancreatic Stem Cells Generated by Transient Overexpression of Reprogramming Factors.Journal of clinical medicine · 2021Article
- Kyoto probe-1 reveals phenotypic differences between mouse ES cells and iTS-P cells.Scientific reports · 2020Article
- Drug-Induced Naïve iPS Cells Exhibit Better Performance than Primed iPS Cells with Respect to the Ability to Differentiate into Pancreatic β-Cell Lineage.Journal of clinical medicine · 2020Article
- Advances in regenerative therapy: A review of the literature and future directions.Regenerative therapy · 2020Review
- Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors.Molecular therapy. Methods & clinical development · 2019Article
- Repeated human deciduous tooth-derived dental pulp cell reprogramming factor transfection yields multipotent intermediate cells with enhanced iPS cell formation capability.Scientific reports · 2019Article
- Induction of Expandable Adipose-Derived Mesenchymal Stem Cells from Aged Mesenchymal Stem Cells by a Synthetic Self-Replicating RNA.International journal of molecular sciences · 2018Article
- Characterization of induced tissue-specific stem cells from pancreas by a synthetic self-replicative RNA.Scientific reports · 2018Article
- Atorvastatin Inhibits the HIF1α-PPAR Axis, Which Is Essential for Maintaining the Function of Human Induced Pluripotent Stem Cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Adhesion characteristics of porcine pancreatic islets and exocrine tissue to coating materials.Islets · 2018Article
- Induced Tissue-Specific Stem Cells and Epigenetic Memory in Induced Pluripotent Stem Cells.International journal of molecular sciences · 2018Review
- A Comparison of Pancreatic Islet Purification using Iodixanol with University of Wisconsin Solution and with Na-Lactobionate and Histidine Solution.Cell medicine · 2018Article
- Role of Egr1 on Pancreatic Endoderm Differentiation.Cell medicine · 2018Article
- The Development of Cancer through the Transient Overexpression of Reprogramming Factors.Cell medicine · 2018Article
- Differential regulated microRNA by wild type and mutant p53 in induced pluripotent stem cells.Cell death & disease · 2016Article
- [Research progress on disease models and gene therapy of Duchenne muscular dystrophy].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although induced pluripotent stem (iPS) cells have significant implications for overcoming most of the ethical issues associated with embryonic stem (ES) cells, there are still several unresolved issues related to the use of iPS cells for clinical applications, such as teratoma formation. In this study, we were able to generate tissue-specific stem (induced tissue-specific stem; iTS) cells from the pancreas (iTS-P) or liver (iTS-L) by transient overexpression of reprogramming factors, combined with tissue-specific selection. The generation of iTS cells was easier than that of iPS cells. The iTS-P/iTS-L cells express genetic markers of endoderm and pancreatic/hepatic progenitors and were able to differentiate into insulin-producing cells/hepatocytes more efficiently than ES cells. Subcutaneous transplantation of both types of iTS cells into immunodeficient mice resulted in no teratoma formation. The technology used for the transient overexpression of reprogramming factors and tissue-specific selection may be useful for the generation of other tissue-specific stem cells, and the generation of iTS cells could have important implications for the clinical application of stem cells.
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