ArticleNature communications2014
The Glanville fritillary genome retains an ancient karyotype and reveals selective chromosomal fusions in Lepidoptera.
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Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 1 of them a synthesis that pooled it.
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115citing papers in PubMed, 1 pooled it
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115 citing papers in PubMed, 1 synthesis or guideline pooled it, 239 citations in OpenAlex.
- Speciation through chromosomal fusion and fission in Lepidoptera.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Pooled it
- Long-read, high-coverage reference genome of the nymphalid butterfly Catonephele acontius (Nymphalidae: Biblidinae).G3 (Bethesda, Md.) · 2026Article
- Comparative Genomics Provide Insights Into Karyotype Evolution in Vespertilionid Bats (Vespertilionidae, Chiroptera).Molecular ecology resources · 2026Article
- A high-quality draft genome assembly of the Neotropical butterfly, Batesia hypochlora (Nymphalidae: Biblidinae).BMC genomics · 2025Article
- Lepidopteran Genomes Have Denser Transposable Elements in Smaller Chromosomes, Likely Driven by Non-allelic Homologous Recombination.Genome biology and evolution · 2025Article
- Fusion, fission, and scrambling of the bilaterian genome in Bryozoa.Genome research · 2025Article
- De Novo Genome Assembly and Annotation for the Synanthropic Webbing Clothes Moth (Tineola bisselliella): A Globally Distributed, Economically Important Pest.Genome biology and evolution · 2024Article
- The Genome Architecture of the Copepod Eurytemora carolleeae - the Highly Invasive Atlantic Clade of the Eurytemoraaffinis Species Complex.Genomics, proteomics & bioinformatics · 2024Article
- Holocentric repeat landscapes: From micro-evolutionary patterns to macro-evolutionary associations with karyotype evolution.Molecular ecology · 2024Article
- Sex-biased gene content is associated with sex chromosome turnover in Danaini butterflies.Molecular ecology · 2024Article
- Genomic hotspots of chromosome rearrangements explain conserved synteny despite high rates of chromosome evolution in a holocentric lineage.Molecular ecology · 2024Article
- A macroevolutionary role for chromosomal fusion and fission inScience advances · 2024Article
- Comparative genomics reveals the dynamics of chromosome evolution in Lepidoptera.Nature ecology & evolution · 2024Article
- Evidence of Nonrandom Patterns of Functional Chromosome Organization in Danaus plexippus.Genome biology and evolution · 2024Article
- The chromosome-scale genome assembly for the West Nile vector Culex quinquefasciatus uncovers patterns of genome evolution in mosquitoes.BMC biology · 2024Article
- Unraveling the complex evolutionary history of lepidopteran chromosomes through ancestral chromosome reconstruction and novel chromosome nomenclature.BMC biology · 2023Article
- The Impact of Chromosomal Rearrangements in Speciation: From Micro- to Macroevolution.Cold Spring Harbor perspectives in biology · 2023Review
- Chromosomal-level Genome Assembly of the Coffee Bee Hawk Moth Reveals the Evolution of Chromosomes and the Molecular Basis of Distinct Phenotypes.Genome biology and evolution · 2023Article
- Lepidopteran Synteny Units reveal deep chromosomal conservation in butterflies and moths.G3 (Bethesda, Md.) · 2023Article
- High-quality haploid genomes corroborate 29 chromosomes and highly conserved synteny of genes in Hyles hawkmoths (Lepidoptera: Sphingidae).BMC genomics · 2023Article
55 more citing papers are in PubMed but not listed here.
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Authors and funding
47 authors at 16 institutions in 7 countries.
Virpi Ahola1] Department of Biosciences, University of Helsinki, FI-00014 Helsinki, Finland [2].
Rainer Lehtonen1] Department of Biosciences, University of Helsinki, FI-00014 Helsinki, Finland [2] Genome-Scale Biology Research Program, University of Helsinki, FI-00014 Helsinki, Finland [3] Institute of Biomedicine, University of Helsinki, FI-00014 Helsinki, Finland [4] Center of Excellence in Cancer Genetics, University of Helsinki, FI-00014 Helsinki, Finland [5] [6].
Panu Somervuo1] Department of Biosciences, University of Helsinki, FI-00014 Helsinki, Finland [2] Institute of Biotechnology, University of Helsinki, FI-00014 Helsinki, Finland [3].
Leena SalmelaDepartment of Computer Science &Helsinki Institute for Information Technology HIIT, University of Helsinki, FI-00014 Helsinki, Finland.
Patrik Koskinen1] Department of Biosciences, University of Helsinki, FI-00014 Helsinki, Finland [2] Institute of Biotechnology, University of Helsinki, FI-00014 Helsinki, Finland.
Pasi RastasDepartment of Biosciences, University of Helsinki, FI-00014 Helsinki, Finland.
Niko Välimäki1] Genome-Scale Biology Research Program, University of Helsinki, FI-00014 Helsinki, Finland [2] Institute of Biomedicine, University of Helsinki, FI-00014 Helsinki, Finland.
Lars PaulinInstitute of Biotechnology, University of Helsinki, FI-00014 Helsinki, Finland.
Jouni KvistInstitute of Biotechnology, University of Helsinki, FI-00014 Helsinki, Finland.
Niklas WahlbergDepartment of Biology, University of Turku, FI-20014 Turku, Finland.
Jaakko Tanskanen1] Institute of Biotechnology, University of Helsinki, FI-00014 Helsinki, Finland [2] Biotechnology and Food Research, MTT Agrifood Research Finland, FI-31600 Jokioinen, Finland.
Emily A Hornett1] Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK [2] Department of Biology, Pennsylvania State University, Pennsylvania 16802, USA.
Laura C FergusonDepartment of Zoology, University of Oxford, Oxford OX1 3PS, UK.
Shiqi LuoCollege of Life Sciences, Peking University, Beijing 100871, P.R. China.
Zijuan CaoCollege of Life Sciences, Peking University, Beijing 100871, P.R. China.
Maaike A de Jong1] Department of Biosciences, University of Helsinki, FI-00014 Helsinki, Finland [2] School of Biological Sciences, University of Bristol, Bristol BS8 1UG, UK.
Anne DuplouyDepartment of Biosciences, University of Helsinki, FI-00014 Helsinki, Finland.
Olli-Pekka SmolanderInstitute of Biotechnology, University of Helsinki, FI-00014 Helsinki, Finland.
Heiko VogelDepartment of Entomology, Max Planck Institute for Chemical Ecology, D-07745 Jena, Germany.
Rajiv C McCoyDepartment of Biology, Stanford University, Stanford, California 94305, USA.
Kui QianInstitute of Biotechnology, University of Helsinki, FI-00014 Helsinki, Finland.
Wong Swee ChongDepartment of Biosciences, University of Helsinki, FI-00014 Helsinki, Finland.
Qin ZhangBioMediTech, University of Tampere, FI-33520 Tampere, Finland.
Freed AhmadDepartment of Information Technology, University of Turku, FI-20014 Turku, Finland.
Jani K HaukkaBioMediTech, University of Tampere, FI-33520 Tampere, Finland.
Aruj JoshiBioMediTech, University of Tampere, FI-33520 Tampere, Finland.
Jarkko SalojärviDepartment of Biosciences, University of Helsinki, FI-00014 Helsinki, Finland.
Christopher W WheatDepartment of Zoology, Stockholm University, SE-10691 Stockholm, Sweden.
Ewald Grosse-WildeDepartment of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, D-07745 Jena, Germany.
Daniel Hughes1] European Bioinformatics Institute, Hinxton CB10 1SD, UK [2] Baylor College of Medicine, Human Genome Sequencing Center, Houston, Texas 77030-3411, USA.
Riku Katainen1] Genome-Scale Biology Research Program, University of Helsinki, FI-00014 Helsinki, Finland [2] Institute of Biomedicine, University of Helsinki, FI-00014 Helsinki, Finland.
Esa Pitkänen1] Genome-Scale Biology Research Program, University of Helsinki, FI-00014 Helsinki, Finland [2] Institute of Biomedicine, University of Helsinki, FI-00014 Helsinki, Finland.
Johannes YlinenDepartment of Computer Science &Helsinki Institute for Information Technology HIIT, University of Helsinki, FI-00014 Helsinki, Finland.
Robert M Waterhouse1] Department of Genetic Medicine and Development, University of Geneva Medical School &Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland [2] Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [3] The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
Mikko TurunenGenome-Scale Biology Research Program, University of Helsinki, FI-00014 Helsinki, Finland.
Anna Vähärautio1] Genome-Scale Biology Research Program, University of Helsinki, FI-00014 Helsinki, Finland [2] Department of Pathology, University of Helsinki, FI-00014 Helsinki, Finland [3] Science for Life Laboratory, Department of Biosciences and Nutrition, Karolinska Institutet, SE-14183 Stockholm, Sweden.
Sami P OjanenDepartment of Biosciences, University of Helsinki, FI-00014 Helsinki, Finland.
Alan H Schulman1] Institute of Biotechnology, University of Helsinki, FI-00014 Helsinki, Finland [2] Biotechnology and Food Research, MTT Agrifood Research Finland, FI-31600 Jokioinen, Finland.
Minna Taipale1] Genome-Scale Biology Research Program, University of Helsinki, FI-00014 Helsinki, Finland [2] Science for Life Laboratory, Department of Biosciences and Nutrition, Karolinska Institutet, SE-14183 Stockholm, Sweden.
Daniel LawsonEuropean Bioinformatics Institute, Hinxton CB10 1SD, UK.
Esko UkkonenDepartment of Computer Science &Helsinki Institute for Information Technology HIIT, University of Helsinki, FI-00014 Helsinki, Finland.
Veli MäkinenDepartment of Computer Science &Helsinki Institute for Information Technology HIIT, University of Helsinki, FI-00014 Helsinki, Finland.
Marian R GoldsmithDepartment of Biological Sciences, University of Rhode Island, Kingston, Rhode Island 02881-0816, USA.
Liisa Holm1] Department of Biosciences, University of Helsinki, FI-00014 Helsinki, Finland [2] Institute of Biotechnology, University of Helsinki, FI-00014 Helsinki, Finland [3].
Petri Auvinen1] Institute of Biotechnology, University of Helsinki, FI-00014 Helsinki, Finland [2].
Mikko J Frilander1] Institute of Biotechnology, University of Helsinki, FI-00014 Helsinki, Finland [2].
Ilkka HanskiDepartment of Biosciences, University of Helsinki, FI-00014 Helsinki, Finland.
University of Helsinki · FIHelsinki Institute of Physics · FIHelsinki Institute for Information Technology · FIEuropean Bioinformatics Institute · GBMax Planck Institute for Chemical Ecology · DEPeking University · CNTampere University · FIUniversity of Turku · FIAgrifood Research Finland · FISIB Swiss Institute of Bioinformatics · CHStanford University · USStockholm University · SETampere University · FIUniversity of Cambridge · GBUniversity of Oxford · GBUniversity of Rhode Island · US
Funding
European Research Council 232826
Abstract
Previous studies have reported that chromosome synteny in Lepidoptera has been well conserved, yet the number of haploid chromosomes varies widely from 5 to 223. Here we report the genome (393 Mb) of the Glanville fritillary butterfly (Melitaea cinxia; Nymphalidae), a widely recognized model species in metapopulation biology and eco-evolutionary research, which has the putative ancestral karyotype of n=31. Using a phylogenetic analyses of Nymphalidae and of other Lepidoptera, combined with orthologue-level comparisons of chromosomes, we conclude that the ancestral lepidopteran karyotype has been n=31 for at least 140 My. We show that fusion chromosomes have retained the ancestral chromosome segments and very few rearrangements have occurred across the fusion sites. The same, shortest ancestral chromosomes have independently participated in fusion events in species with smaller karyotypes. The short chromosomes have higher rearrangement rate than long ones. These characteristics highlight distinctive features of the evolutionary dynamics of butterflies and moths.
Indexed as
Chromosome AberrationsEvolution, MolecularPhylogenySyntenyAnimalsBase SequenceButterfliesChromosome MappingGenomeKaryotypeLikelihood FunctionsModels, GeneticMolecular Sequence DataSequence Analysis, DNA
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