Evidence map›Paper›PMID 25189874›Full record

ArticleGenetics2014

Genetic influences on brain gene expression in rats selected for tameness and aggression.

Henrike O Heyne, Susann Lautenschläger, Ronald Nelson, François Besnier, Maxime Rotival, Alexander Cagan, Rimma Kozhemyakina, Irina Z Plyusnina, Lyudmila Trut, Örjan Carlborg and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 78 citations in OpenAlex.

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  16. Review
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  20. Genomic responses to selection for tame/aggressive behaviors in the silver fox (Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 6 countries.

Henrike O HeyneDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany Institute for Biochemistry, University of Leipzig, Medical Faculty, 04103 Leipzig, Germany henrikeheyne@hotmail.de falbert@mednet.ucla.edu.
Susann LautenschlägerInstitute for Biochemistry, University of Leipzig, Medical Faculty, 04103 Leipzig, Germany.
Ronald NelsonSwedish University of Agricultural Sciences, Department of Clinical Sciences, Division of Computational Genetics, Box 7078 SE-75007 Uppsala, Sweden.
François BesnierSwedish University of Agricultural Sciences, Department of Clinical Sciences, Division of Computational Genetics, Box 7078 SE-75007 Uppsala, Sweden Section of Population Genetics and Ecology, Institute of Marine Research, Havforskningsinstituttet, Nordnes 5817, Bergen, Norway.
Maxime RotivalMRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom.
Alexander CaganDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
Rimma KozhemyakinaInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Irina Z PlyusninaInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Lyudmila TrutInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Örjan CarlborgSwedish University of Agricultural Sciences, Department of Clinical Sciences, Division of Computational Genetics, Box 7078 SE-75007 Uppsala, Sweden.
Enrico PetrettoMRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom.
Leonid KruglyakDepartment of Human Genetics, Gonda Center, University of California, Los Angeles, California 90095 Department of Biological Chemistry, Gonda Center, University of California, Los Angeles, California 90095 Howard Hughes Medical Institute, Gonda Center, University of California, Los Angeles, California 90095.
Svante PääboDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
Torsten SchönebergInstitute for Biochemistry, University of Leipzig, Medical Faculty, 04103 Leipzig, Germany.
Frank W AlbertDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany Department of Human Genetics, Gonda Center, University of California, Los Angeles, California 90095 henrikeheyne@hotmail.de falbert@mednet.ucla.edu.
Institute of Cytology and Genetics · RULeipzig University · DEMax Planck Institute for Evolutionary Anthropology · DESwedish University of Agricultural Sciences · SEImperial College London · GBUniversity of California, Los Angeles · US

Funding

Medical Research Council MC_U120097112
6 · The paper itself

Abstract

Interindividual differences in many behaviors are partly due to genetic differences, but the identification of the genes and variants that influence behavior remains challenging. Here, we studied an F2 intercross of two outbred lines of rats selected for tame and aggressive behavior toward humans for >64 generations. By using a mapping approach that is able to identify genetic loci segregating within the lines, we identified four times more loci influencing tameness and aggression than by an approach that assumes fixation of causative alleles, suggesting that many causative loci were not driven to fixation by the selection. We used RNA sequencing in 150 F2 animals to identify hundreds of loci that influence brain gene expression. Several of these loci colocalize with tameness loci and may reflect the same genetic variants. Through analyses of correlations between allele effects on behavior and gene expression, differential expression between the tame and aggressive rat selection lines, and correlations between gene expression and tameness in F2 animals, we identify the genes Gltscr2, Lgi4, Zfp40, and Slc17a7 as candidate contributors to the strikingly different behavior of the tame and aggressive animals.

Indexed as

AggressionBehavior, AnimalGene Expression RegulationAllelesAnimalsBrainCrosses, GeneticFemaleGene Expression ProfilingGenomeHumansMaleQuantitative Trait LociRatsRNA, MessengerSequence Analysis, RNARNA, Messengerbrain gene expressiongenetics of tame and aggressive behaviornatural variationquantitative trait locus (QTL) mapping in outbred ratsRNA sequencing

Identifiers

PMID25189874
PMCPMC4224166
OpenAlexW2137599563

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.