ArticleProceedings of the National Academy of Sciences of the United States of America2014
Olfactory learning promotes input-specific synaptic plasticity in adult-born neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- Adult-neurogenesis allows for representational stability and flexibility in early olfactory system.eLife · 2026Article
- COVID-19 infection and longitudinal changes in olfactory-related brain structures in children: analysis of ABCD study data.European journal of pediatrics · 2025Observational
- Distinct Ultrastructural Properties and Plasticity of Synapses Formed by Adult-Born and Early-Born Interneurons in the Mouse Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- Timing Matters: Lessons From Perinatal Neurogenesis in the Olfactory Bulb.The Journal of comparative neurology · 2025Article
- Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal.Nature communications · 2025Article
- [Application of optogenetic technology in the research on olfactory bulb neural projection from advanced brain regions to regulate olfactory signal processing].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Review
- Olfactory Epithelium Stimulation Using Rhythmic Nasal Air-Puffs Improves the Cognitive Performance of Individuals with Acute Sleep Deprivation.Brain sciences · 2024Article
- Distinct forms of structural plasticity of adult-born interneuron spines in the mouse olfactory bulb induced by different odor learning paradigms.Communications biology · 2024Article
- Signaling mechanisms underlying activity-dependent integration of adult-born neurons in the mouse olfactory bulb.Genesis (New York, N.Y. : 2000) · 2024Review
- Value-related learning in the olfactory bulb occurs through pathway-dependent perisomatic inhibition of mitral cells.PLoS biology · 2024Article
- Olfactory neurogenesis plays different parts at successive stages of life, implications for mental health.Frontiers in neural circuits · 2024Review
- Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal reward contingency signals during rule-reversal.bioRxiv : the preprint server for biology · 2023Article
- Case report: "Proust phenomenon" after right posterior cerebral artery occlusion.Frontiers in neurology · 2023Article
- Long-range functional loops in the mouse olfactory system and their roles in computing odor identity.Neuron · 2022Article
- Long-range GABAergic projections contribute to cortical feedback control of sensory processing.Nature communications · 2022Article
- Structural spine plasticity: Learning and forgetting of odor-specific subnetworks in the olfactory bulb.PLoS computational biology · 2022Article
- Striatal hub of dynamic and stabilized prediction coding in forebrain networks for olfactory reinforcement learning.Nature communications · 2022Article
- Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine.The Journal of experimental medicine · 2022Article
- Connectivity and dynamics in the olfactory bulb.PLoS computational biology · 2022Article
2 more citing papers are in PubMed but not listed here.
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6 authors.
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Abstract
The production of new neurons in the olfactory bulb (OB) through adulthood is a major mechanism of structural and functional plasticity underlying learning-induced circuit remodeling. The recruitment of adult-born OB neurons depends not only on sensory input but also on the context in which the olfactory stimulus is received. Among the multiple steps of adult neurogenesis, the integration and survival of adult-born neurons are both strongly influenced by olfactory learning. Conversely, optogenetic stimulation of adult-born neurons has been shown to specifically improve olfactory learning and long-term memory. However, the nature of the circuit and the synaptic mechanisms underlying this reciprocal influence are not yet known. Here, we showed that olfactory learning increases the spine density in a region-restricted manner along the dendritic tree of adult-born granule cells (GCs). Anatomical and electrophysiological analysis of adult-born GCs showed that olfactory learning promotes a remodeling of both excitatory and inhibitory inputs selectively in the deep dendritic domain. Circuit mapping revealed that the malleable dendritic portion of adult-born neurons receives excitatory inputs mostly from the regions of the olfactory cortex that project back to the OB. Finally, selective optogenetic stimulation of olfactory cortical projections to the OB showed that learning strengthens these inputs onto adult-born GCs. We conclude that learning promotes input-specific synaptic plasticity in adult-born neurons, which reinforces the top-down influence from the olfactory cortex to early stages of olfactory information processing.
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